*Optimal dilutions/concentrations should be determined by the researcher.
Application
Recommended Dilution
IHC-P
1:300‐1:600
Note :
IHC-P
Recommendations for antigen retrieval : Citrate Buffer pH 6.0 at room temperature for 30 mins.
Not tested in other applications.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
BALB/C mice were injected with a purified human lung tryptase.
Purification
Purified IgG
Conjugation
Unconjugated
RRID
AB_384785
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
![Anti-Mast cell tryptase antibody [AA1] used in IHC (Paraffin sections) (IHC-P). GTX22378](/upload/website/prouct_img/small/GTX22378/GTX22378_20191203_IHC-P_98_w_23060620_641.webp "Anti-Mast cell tryptase antibody [AA1] used in IHC (Paraffin sections) (IHC-P). GTX22378")
![Anti-Mast cell tryptase antibody [AA1] used in IHC (Paraffin sections) (IHC-P). GTX22378](/upload/website/prouct_img/normal/GTX22378/GTX22378_20191203_IHC-P_98_w_23060620_641.webp "Anti-Mast cell tryptase antibody [AA1] used in IHC (Paraffin sections) (IHC-P). GTX22378")