APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 μg/mL |
| 10 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Brain Tissue Slide(GTX22203) , Mouse Brain Tissue Lysate(GTX27934)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
NALP5 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human NALP5.The immunogen is located within the last 50 amino acids of NALP5.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
NLR family pyrin domain containing 5 , CLR19.8 , MATER , NALP5 , PAN11 , PYPAF8
Cellular Localization
Mitochondrion,Cytoplasm,Nucleolus
Background
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
Database
Research Area
DATA IMAGES
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GTX85158 IHC-P Image
IHC-P analysis of human brain tissue using GTX85158 NALP5 antibody.
Working concentration : 20 μg/ml
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GTX85158 IHC-P Image
IHC-P analysis of human brain tissue using GTX85158 NALP5 antibody.
Working concentration : 10 μg/ml
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GTX85158 WB Image
WB analysis of mouse brain tissue lysate in (A) the absence and (B) the presence of blocking peptide using GTX85158 NALP5 antibody.
Working concentration : 1 μg/ml
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REFERENCE
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REVIEW
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