APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
Assay dependent |
4 μg/ml |
Not tested in other applications.
Calculated MW
Predict Reactivity
Rat, Bovine, Dog, Pig, Bat, Elephant, Gibbon, Gorilla, Horse, Marmoset, Opossum, Panda(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic 16 amino acid peptide from ligand-binding domain of human NR0B2.
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
RRID
AB_375398
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
nuclear receptor subfamily 0 group B member 2 , NR0B2 , SHP , SHP1
Cellular Localization
Nucleus,Cytoplasm
Background
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX70897 IHC-P Image
IHC-P analysis of human liver, hepatocytes tissue using GTX70897 NR0B2 antibody. Antigen retrieval : Heat-induced antigen retrieval
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REFERENCE
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REVIEW
There are currently no reviews for NR0B2 antibody (GTX70897). Be the first to share your experience with this product.