Nav1.2 antibody

Cat. No. GTX54797

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IHC-Fr, IP
Reactivity	Human, Mouse, Rat
Package	50 μl ($639)

See all Nav1.2 products

Datasheet
Document

View product citations for antibody GTX54797 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	Assay dependent
ICC/IF	Assay dependent
IHC-Fr	Assay dependent
IP	Assay dependent

Not tested in other applications.

Calculated MW

228 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.8 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Peptide (C)ASAESRDFSGAGGIGVFSE, corresponding to amino acid residues 467-485 (Intracellular loop between domains I and II) of rat NaV1.2 (Accession : P04775).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

sodium voltage-gated channel alpha subunit 2 , NachII , Nav1.2 , RII/RIIA , RNSCPIIR , SCN , Scn2a1 , Scn2a2 , ScpII

Cellular Localization

Cell membrane

Background

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. In humans, variants of this gene are associated with seizure disorders and autism spectrum disorder. Mice homozygous for a knockout mutation die with severe hypoxia and extensive neuronal cell death, while gain of function mutations result in progressive seizure disorder. [provided by RefSeq, Nov 2016]

Database

Gene ID: 24766 Scn2a
UniProt: P04775 Scn2a

Research Area

DATA IMAGES

GTX54797 WB Image

WB analysis of rat brain membrane lysate using GTX54797 Nav1.2 antibody preincubated with or without immunogen peptide.
Dilution : 1:200

GTX54797 IP Image

IP analysis of rat brain tissue lysate using GTX54797 Nav1.2 antibody. The lower arrow indicates the IgG heavy chain.WB was performed with the GTX54797 antibody.
IP reaction : 6 μg
Lane 1 : Rat brain lysates
Lane 2 : Lysates immunoprecipitated with Anti-SCN2A (NaV1.2) Antibody
Lane 3 : Lysates immunoprecipitated with pre-immune rabbit serum

GTX54797 IHC-Fr Image

IHC-Fr analysis of mouse hippocampus tissue using GTX54797 Nav1.2 antibody.
Panel A : NaV1.2 (red) is present in dendrites of pyramidal neurons in the CA3 region.
Panel B : Staining of interneurons in the pyramidal layer with mouse anti-Parvalbumin (green) demonstrates the restriction of NaV1.2 to dendrites (arrows) extending from the pyramidal layer (P).
Panel C : Confocal merge of panels A and B.

REFERENCE

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SDS
PBS.pdf
Sodium Azide.pdf

Package

List Price ($)

50 μl

$ 639

Qty