APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 5 - 10 μg/mL |
| 2.5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Daudi Cell Lysate(GTX23951) , Mouse Heart Tissue Lysate(GTX27932)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Neuritin antibody was raised against a 20 amino acid synthetic peptide from near the center of human neuritin.The immunogen is located within amino acids 70 - 120 of Neuritin.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
neuritin 1 , NRN , dJ380B8.2
Cellular Localization
Cell membrane,Cell junction, synapse
Background
As the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites. This synaptic remodeling involves neuro-transmitter signaling, activation of neurotrophin receptors and alterations in gene expression. One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system. Its expression is also induced by the neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth. More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.
Database
Research Area
DATA IMAGES
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GTX85446 IHC-P Image
IHC-P analysis of human brain tissue using GTX85446 Neuritin antibody.
Working concentration : 2.5 μg/ml
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GTX85446 IHC-P Image
IHC-P analysis of mouse heart tissue using GTX85446 Neuritin antibody.
Working concentration : 20 μg/ml
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GTX85446 IHC-P Image
IHC-P analysis of mouse heart tissue using GTX85446 Neuritin antibody.
Working concentration : 5 μg/ml
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GTX85446 WB Image
WB analysis of Daudi cell lysate using GTX85446 Neuritin antibody.
Working concentration : (A) 5 and (B) 10 μg/ml
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GTX85446 IHC-P Image
IHC-P analysis of human brain tissue using GTX85446 Neuritin antibody.
Green : Primary antibody
Blue : DAPI
Dilution : 20 μg/ml
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REFERENCE
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REVIEW
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