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Neurofibromin antibody

KO/KD
Anti-Neurofibromin antibody used in Western Blot (WB). GTX28132
Anti-Neurofibromin antibody used in IHC (Paraffin sections) (IHC-P). GTX28132

Cat. No. GTX28132

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC-Fr

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all Neurofibromin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
ICC/IF Assay dependent
IHC-P 1:200 - 1:500
IHC-Fr 1:200 - 1:500
Not tested in other applications.

Calculated MW

319 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Serum

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

An N-terminal peptide of Neurofibromin 1 (within amino acids 1-50). [UniProt# P21359]

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

neurofibromin 1 , NFNS , VRNF , WSS

Cellular Localization

Nucleus,Nucleolus

Background

This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-Neurofibromin antibody used in Western Blot (WB). GTX28132

GTX28132 WB Image

KO/KD

WB analysis of (A) Neurofibromin knockout cell, (B) rat Schwann cell, and (C) human Schwann cell lysate using GTX28132 Neurofibromin antibody.

Anti-Neurofibromin antibody used in IHC (Paraffin sections) (IHC-P). GTX28132

GTX28132 IHC-P Image

IHC-P analysis of maturing and the hypertrophic cartilage tissue using GTX28132 Neurofibromin antibody.

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399