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PD-L1 antibody [405-9A11]

Anti-PD-L1 antibody [405-9A11] used in IHC (Paraffin sections) (IHC-P). GTX03297

Cat. No. GTX03297

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 405-9A11

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($519)
See all PD-L1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:50-1:100

Note :

IHC-P
Pretreatment : EDTA Buffer pH 8.0 for 30 min at RT
Not tested in other applications.

Calculated MW

33 kDa. ( Note )

Positive Control

Lung squamous carcinoma

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

coupled to KLH, Last 19 amino acids at the carboxy-terminus of the human membrane-bound PDL1 polypeptide

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD274 molecule , B7-H , B7H1 , PD-L1 , PDCD1L1 , PDCD1LG1 , PDL1

Cellular Localization

Cell membrane

Background

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Database

Research Area

DATA IMAGES

Anti-PD-L1 antibody [405-9A11] used in IHC (Paraffin sections) (IHC-P). GTX03297

GTX03297 IHC-P Image

IHC-P analysis of human squamous lung carcinoma tissue section using GTX03297 PD-L1 antibody [405-9A11].

REFERENCE

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REVIEW

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Package List Price ($)
$ 519