APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500 - 1:2000 |
| 1:50 - 1:200 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 157-416 of human PSTPIP1 (NP_003969.2).
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
proline-serine-threonine phosphatase interacting protein 1 , CD2BP1 , CD2BP1L , CD2BP1S , H-PIP , PAPAS , PSTPIP
Cellular Localization
Cytoplasm,Cell membrane,Cytoplasm, cytoskeleton
Background
This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016]
Database
Research Area
DATA IMAGES
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GTX33443 WB Image
WB analysis of various sample lysates using GTX33443 PSTPIP1 antibody.
Dilution : 1:1000
Loading : 25μg per lane
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GTX33443 IHC-P Image
IHC-P analysis of human stomach tissue using GTX33443 PSTPIP1 antibody.
Dilution : 1:100
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GTX33443 IHC-P Image
IHC-P analysis of mouse kidney tissue using GTX33443 PSTPIP1 antibody.
Dilution : 1:100
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REFERENCE
There are currently no references for PSTPIP1 antibody (GTX33443). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for PSTPIP1 antibody (GTX33443). Be the first to share your experience with this product.
