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PTPN3 antibody

Anti-PTPN3 antibody used in Western Blot (WB). GTX54572
Anti-PTPN3 antibody used in IHC (Paraffin sections) (IHC-P). GTX54572
Anti-PTPN3 antibody used in IHC (Paraffin sections) (IHC-P). GTX54572

Cat. No. GTX54572

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all PTPN3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

104 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PTPN3 (NP_001138840.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_2887864

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

protein tyrosine phosphatase non-receptor type 3 , PTP-H1 , PTPH1

Cellular Localization

Cytoplasm, cytoskeleton

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Database

Research Area

DATA IMAGES

Anti-PTPN3 antibody used in Western Blot (WB). GTX54572

GTX54572 WB Image

WB analysis of various sample lysates using GTX54572 PTPN3 antibody. The signal was developed with ECL plus-Enhanced.
Dilution : 1:1000
Loading : 25μg per lane

Anti-PTPN3 antibody used in IHC (Paraffin sections) (IHC-P). GTX54572

GTX54572 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX54572 PTPN3 antibody.
Dilution : 1:100

Anti-PTPN3 antibody used in IHC (Paraffin sections) (IHC-P). GTX54572

GTX54572 IHC-P Image

IHC-P analysis of rat brain tissue using GTX54572 PTPN3 antibody.
Dilution : 1:100

REFERENCE

Application Reference

Peng XS et al. Mol Cancer Res 2020; 18 (6) : 903-912 PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling.
Application : WB, IHC-P
Reactivity : Human
Submit a Reference

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399