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Phospholamban antibody

Anti-Phospholamban antibody used in Western Blot (WB). GTX37204

Cat. No. GTX37204

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Rat
Package
100 μg ($549)
See all Phospholamban products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
Not tested in other applications.

Calculated MW

6 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.001% Na₂HPO₄, 0.0045% NaCl, 0.025% BSA

Preservative

0.00025% Thimerosal, 0.00025% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human PLN(2-16aa EKVQYLTRSAIRRAS), identical to the related rat and mouse sequences.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

phospholamban , CMD1P , CMH18 , PLB

Cellular Localization

Endoplasmic reticulum membrane,Membrane

Background

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]

Database

Research Area

DATA IMAGES

Anti-Phospholamban antibody used in Western Blot (WB). GTX37204

GTX37204 WB Image

WB analysis of rat heart tissue lysate using GTX37204 Phospholamban antibody.

REFERENCE

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REVIEW

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SDS
Thimerosal.pdf
Package List Price ($)
$ 549