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RyR2 antibody

Anti-RyR2 antibody used in IHC (Paraffin sections) (IHC-P). GTX87462
Anti-RyR2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX87462

Cat. No. GTX87462

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 ICC/IF, IHC-P

Reactivity

 Human, Mouse
Package
100 μg ($399)
See all RYR2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF 1:100 - 1:500
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

565 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized peptide derived from Internal of human RyR2.

Purification

Purified by antigen-affinity chromatography
From serum

Conjugation

Unconjugated

RRID

AB_10725528

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ARVC2,ARVD2,RYR2,RyR,VTSIP,ryanodine receptor 2,Ryanodine Receptor 2

Cellular Localization

Sarcoplasmic reticulum membrane,Membrane,Sarcoplasmic reticulum

Background

This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-RyR2 antibody used in IHC (Paraffin sections) (IHC-P). GTX87462

GTX87462 IHC-P Image

IHC-P analysis of human brain tissue using GTX87462 RyR2 antibody.

Anti-RyR2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX87462

GTX87462 ICC/IF Image

ICC/IF analysis of NIH/3T3 cells using GTX87462 RyR2 antibody.

REFERENCE

Application Reference

Martewicz S et al. Stem Cell Research 2017; : Epub ahead of print Substrate and mechanotransduction influence SERCA2a localization in human pluripotent stem cell-derived cardiomyocytes affecting functional performance.
Application : ICC/IF
Reactivity : Human
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Package List Price ($)
$ 399