APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 0.5 - 2 μg/mL |
| 2.5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
HL60 Cell Lysate(GTX27914) , Human Liver Tissue Slide
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
SCO2 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human SCO2.The immunogen is located within the last 50 amino acids of SCO2.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
SCO cytochrome c oxidase assembly protein 2 , CEMCOX1 , ECGF1 , Gliostatin , MYP6 , PD-ECGF , SCO1L , TP , TYMP , TdRPase
Cellular Localization
Mitochondrion inner membrane
Background
Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.
Database
Research Area
DATA IMAGES
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GTX85482 IHC-P Image
IHC-P analysis of human liver tissue using GTX85482 SCO2 antibody.
Working concentration : 20 μg/ml
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GTX85482 WB Image
WB analysis of HL-60 cell lysate using GTX85482 SCO2 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml
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GTX85482 IHC-P Image
IHC-P analysis of human liver tissue using GTX85482 SCO2 antibody.
Working concentration : 2.5 μg/ml
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REFERENCE
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REVIEW
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