APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 μg/mL |
| 2.5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Brain Tissue Slide(GTX22203) , 3T3 (NIH) Cell Lysate(GTX27179)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
SHANK3 antibody was raised against a 19 amino acid synthetic peptide near the center of human SHANK3.The immunogen is located within amino acids 890 - 940 of SHANK3.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
SH3 and multiple ankyrin repeat domains 3 , DEL22q13.3 , PROSAP2 , PSAP2 , SCZD15 , SPANK-2
Cellular Localization
Cytoplasm
Background
This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012]
Database
Research Area
DATA IMAGES
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GTX31480 WB Image
WB analysis of 3T3 cell lysate in (A) the absence and (B) the presence of blocking peptide using GTX31480 SHANK3 antibody.
Working concentration : 1 μg/ml
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GTX31480 IHC-P Image
IHC-P analysis of human brain tissue using GTX31480 SHANK3 antibody.
Working concentration : 2.5 μg/ml
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GTX31480 IHC-P Image
IHC-P analysis of human brain tissue using GTX31480 SHANK3 antibody.
Working concentration : 20 μg/ml
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REFERENCE
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REVIEW
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