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Survivin antibody [32.1]

Anti-Survivin antibody [32.1] used in IHC (Paraffin sections) (IHC-P). GTX10584

Cat. No. GTX10584

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 32.1

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, IP, ELISA

Reactivity

 Human, Hamster
Package
100 μl ($419)
See all Survivin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000
ICC/IF 1:10 - 1:500
IHC-P 20 μg/ml
IP Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

16 kDa. ( Note )

Product Note

This antibody is specific for the nuclear form of survivin.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.9 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Full length recombinant human Survivin [UniProt# O15392]

Purification

Protein G purified

Conjugation

Unconjugated

RRID

AB_367870

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

baculoviral IAP repeat containing 5 , API4 , EPR-1

Cellular Localization

Cytoplasm,Nucleus

Background

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-Survivin antibody [32.1] used in IHC (Paraffin sections) (IHC-P). GTX10584

GTX10584 IHC-P Image

IHC-P analysis of human lung cancer tissue using GTX10584 Survivin antibody [32.1].

REFERENCE

Application Reference

Vargiolu M et al. J Clin Endocrinol Metab 2009; 94 (7) : 245292 The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 419