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Syntrophin alpha 1 antibody [AT1E1]

Anti-Syntrophin alpha 1 antibody [AT1E1] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX57590
Anti-Syntrophin alpha 1 antibody [AT1E1] used in Western Blot (WB). GTX57590

Cat. No. GTX57590

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 AT1E1

Isotype

 IgG2b

Application

 WB, ICC/IF

Reactivity

 Human
Package
100 μl ($399)
See all Syntrophin alpha 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Recommended starting dilution is 1:1000.
ICC/IF Assay dependent
Not tested in other applications.

Calculated MW

54 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 10% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The clone AT1E1 is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human SNTA3 protein.

Purification

Protein A Purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

syntrophin alpha 1 , LQT12 , SNT1 , SNTA1 , TACIP1 , dJ1187J4.5 , Syntrophin alpha 1

Cellular Localization

Cell membrane,Sarcolemma,Cell junction,Cytoplasm,Cytoskeleton

Background

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]

Database

Research Area

DATA IMAGES

Anti-Syntrophin alpha 1 antibody [AT1E1] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX57590

GTX57590 ICC/IF Image

ICC/IF analysis of HeLa cells using GTX57590 Syntrophin alpha 1 antibody.
Blue: DAPI
Green: Primary antibody
Dilution: 1:100

Anti-Syntrophin alpha 1 antibody [AT1E1] used in Western Blot (WB). GTX57590

GTX57590 WB Image

WB analysis of HepG2 whole cell lysate using GTX57590 Syntrophin alpha 1 antibody.
Loading : 40 μg
Dilution : 1:1000

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399