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TCF4 antibody [TCF4/1705]

Anti-TCF4 antibody [TCF4/1705] used in Protein Array (Protein Array). GTX17912
Anti-TCF4 antibody [TCF4/1705] used in Western Blot (WB). GTX17912

Cat. No. GTX17912

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 TCF4/1705

Isotype

 IgG2a

Application

 WB, ELISA, Protein Array

Reactivity

 Human
Package
100 μg ($529)
See all TCF4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1-2μg/ml
ELISA 2-4μg/ml (for coating)
Protein Array Assay dependent

Note :

ELISA
For ELISA coating, recommend using BSA-free format (please contact us for PBS only format).
Not tested in other applications.

Calculated MW

71 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human TCF4 protein fragment (around aa 365-671) (exact sequence is proprietary)

Purification

Protein A/G purified

Conjugation

Unconjugated

RRID

AB_2887569

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

E22 , FECD3 , ITF2 , PTHS , SEF2 , SEF21 , SEF21A , SEF21B , SEF21D , TCF4 , bHLHb19 , transcription factor 4

Cellular Localization

Nucleus

Background

This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]

Database

Research Area

DATA IMAGES

Anti-TCF4 antibody [TCF4/1705] used in Protein Array (Protein Array). GTX17912

GTX17912 Protein Array Image

Analysis of Protein Array containing more than 19,000 full-length human proteins using TCF4 Mouse Monoclonal Antibody (TCF4/1705). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Anti-TCF4 antibody [TCF4/1705] used in Western Blot (WB). GTX17912

GTX17912 WB Image

WB analysis of (1) HeLa and (2) HepG2 cell lysates using GTX17912 TCF4 antibody [TCF4/1705].

REFERENCE

Application Reference

Hsu YH et al. iScience 2023; 26 (5) : 106701 Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
Wen N et al. J Int Med Res 2020; 48 (1) : 3.00061E+14 Overexpression of cell-cycle related and expression-elevated protein in tumor (CREPT) in malignant cervical cancer.
Application : WB
Reactivity : Human
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 529