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TCL1A antibody [TCL1/2078]

Anti-TCL1A antibody [TCL1/2078] used in IHC (Paraffin sections) (IHC-P). GTX17841
Anti-TCL1A antibody [TCL1/2078] used in IHC (Paraffin sections) (IHC-P). GTX17841
Anti-TCL1A antibody [TCL1/2078] used in Protein Array (Protein Array). GTX17841

Cat. No. GTX17841

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 TCL1/2078

Isotype

 IgG1

Application

 IHC-P, Protein Array

Reactivity

 Human
Package
100 μg ($529)
See all TCL1A products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1-2μg/ml for 30 minutes at RT
Protein Array Assay dependent

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

13 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human TCL1 protein fragment (around aa 2-109) (exact sequence is proprietary)

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TCL1 , TCL1A , Tcell leukemia/lymphoma 1A , T cell leukemia/lymphoma 1A

Cellular Localization

Cytoplasm,Nucleus,Microsome,Endoplasmic reticulum

Background

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

Database

Research Area

DATA IMAGES

Anti-TCL1A antibody [TCL1/2078] used in IHC (Paraffin sections) (IHC-P). GTX17841

GTX17841 IHC-P Image

IHC-P analysis of human spleen tissue using GTX17841 TCL1A antibody [TCL1/2078].

Anti-TCL1A antibody [TCL1/2078] used in IHC (Paraffin sections) (IHC-P). GTX17841

GTX17841 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX17841 TCL1A antibody [TCL1/2078].

Anti-TCL1A antibody [TCL1/2078] used in Protein Array (Protein Array). GTX17841

GTX17841 Protein Array Image

Analysis of Protein Array containing more than 19,000 full-length human proteins using TCL1 Mouse Monoclonal Antibody (TCL1/2078). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 529