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TCTN1 antibody

Anti-TCTN1 antibody used in Western Blot (WB). GTX85178
Anti-TCTN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85178
Anti-TCTN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85178

Cat. No. GTX85178

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse
Package
100 μg ($399)
See all TCTN1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

64 kDa. ( Note )

Positive Control

Mouse Kidney Tissue Lysate(GTX27936) , Human Kidney Tissue Slide

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

TCTN1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human TCTN1.The immunogen is located within amino acids 30 - 80 of TCTN1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tectonic family member 1 , JBTS13 , TECT1

Cellular Localization

Secreted

Background

TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

Database

Research Area

DATA IMAGES

Anti-TCTN1 antibody used in Western Blot (WB). GTX85178

GTX85178 WB Image

WB analysis of mouse kidney tissue lysate using GTX85178 TCTN1 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Anti-TCTN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85178

GTX85178 IHC-P Image

IHC-P analysis of human kidney tissue using GTX85178 TCTN1 antibody.
Working concentration : 5 μg/ml

Anti-TCTN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85178

GTX85178 IHC-P Image

IHC-P analysis of human kidney tissue using GTX85178 TCTN1 antibody.
Working concentration : 20 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399