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TEM4 antibody

Anti-TEM4 antibody used in Western Blot (WB). GTX85426
Anti-TEM4 antibody used in IHC (Paraffin sections) (IHC-P). GTX85426

Cat. No. GTX85426

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human
Package
100 μg ($399)
See all TEM4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5 - 1 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

222 kDa. ( Note )

Positive Control

Jurkat Cell Lysate(GTX27899) , Human Spleen Tissue Slide

Product Note

This antibody is specific for TEM4 Internal

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

TEM4 antibody was raised against a 18 amino acid synthetic peptide near the center of human TEM4.The immunogen is located within amino acids 910 - 960 of TEM4.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Rho guanine nucleotide exchange factor 17 , P164RHOGEF , RHOGEF17 , TEM4 , p164-RhoGEF

Background

Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.

Database

DATA IMAGES

Anti-TEM4 antibody used in Western Blot (WB). GTX85426

GTX85426 WB Image

WB analysis of Jurkat cell lysate using GTX85426 TEM4 antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml

Anti-TEM4 antibody used in IHC (Paraffin sections) (IHC-P). GTX85426

GTX85426 IHC-P Image

IHC-P analysis of human spleen tissue using GTX85426 TEM4 antibody.
Working concentration : 2.5 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399