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United States (US)

TGF beta Receptor antibody

Cat. No. GTX17282

Host

 Sheep

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC

Reactivity

 Bird
Package
50 μg ($399)
See all TGF beta Receptor products

APPLICATION

Application Note

IHC: Use at an assay dependent dilution. WB: 1/100. Predicted molecular weight: 68 kDa. Optimal dilutions/concentrations should be determined by the end user.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.08% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

GST fusion avian protein, containing chick transforming growth factor b type II receptor (aa 77 - 148).

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Transforming growth factor beta receptor II (70-80kDa) , TGF beta receptor , Transforming growth factor beta receptor II , TGF beta receptor type II precursor , TGF beta type II receptor , Transforming growth factor beta receptor II (7080kDa) , TGFR2

Cellular Localization

Type I membrane protein

Background

Three members of the TGF beta family, TGF beta 1, TGF beta 2 and TGF beta 3, are known in mammals. TGF betas mediate their activity by high affinity binding to the type 2 receptor, which requires both its kinase activity and association with members of a series of related type 1 receptors called activin receptor-like kinase (ALK) 1 to 6. Of these, only ALK5 has been shown to represent a functional TGF beta type 1 receptor, but only ALK2 and ALK4 bind activin with high affinity. TGF beta R3 binds TGF beta and retains TGF beta for presentation to the signaling receptors.

Research Area

REFERENCE

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399