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TIRAP antibody [20D1055]

Anti-TIRAP antibody [20D1055] used in Western Blot (WB). GTX13684

Cat. No. GTX13684

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 20D1055

Isotype

 IgM

Application

 WB

Reactivity

 Human
Package
1 ml ($399)
See all TIRAP products

APPLICATION

Application Note

WB: Use at a dilution of 1/100. Detects a band of approximately 32-37 kDa (predicted molecular weight: 26.5 kDa). Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

24 kDa. ( Note )

Positive Control

HUVEC cell lysate.

PROPERTIES

Form

Liquid

Buffer

Ascites, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive)

Purification

Tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TIR domain containing adaptor protein , BACTS1 , Mal , MyD88-2 , wyatt

Cellular Localization

Cytoplasm , Cell membrane , Membrane

Background

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-TIRAP antibody [20D1055] used in Western Blot (WB). GTX13684

GTX13684 WB Image

Western blot analysis of TIRAP in human spleen lysate at 1:500.

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399