TrkB (phospho Tyr515) antibody

Cat. No. GTX86536

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P
Reactivity	Human, Mouse
Package	100 μg ($399)

See all TrkB products

Datasheet

View product citations for antibody GTX86536 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:500 - 1:3000
IHC-P	1:50 - 1:100

Not tested in other applications.

Calculated MW

92 kDa. ( Note )

Predict Reactivity

Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human Trk B around the phosphorylation site of tyrosine 515 (P-Q-Yp-F-G).

Purification

Purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.
From serum

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

GP145TrkB,NTRK2,TRKB,neurotrophic receptor tyrosine kinase 2,trkB,TrkB,Trk B

Cellular Localization

Cell membrane,Endosome membrane,Early endosome membrane

Background

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Database

Gene ID: 4915 NTRK2
UniProt: Q16620 NTRK2

Research Area

DATA IMAGES

GTX86536 WB Image

WB analysis of NIH/3T3 cell lysate using GTX86536 TrkB (phospho Tyr515) antibody.

GTX86536 IHC-P Image

IHC-P analysis of human brain tissue using GTX86536 TrkB (phospho Tyr515) antibody.

REFERENCE

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REVIEW

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Package

List Price ($)

100 μg

$ 399

Qty