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UBE3A antibody

Anti-UBE3A antibody used in Immunohistochemistry (IHC). GTX70169

Cat. No. GTX70169

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC

Reactivity

 Human
Package
50 μl ($399)
See all UBE3A products

APPLICATION

Application Note

Optimal dilutions/concentations should be determined by the researcher.

Calculated MW

101 kDa. ( Note )

Positive Control

HeLa

PROPERTIES

Form

Liquid

Buffer

Unpurified Serum

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant protein encoding amino acids residues 1-851 of human UBE3A expressed in E. coli.

Purification

Rabbit Polyclonal Antiserum
Antiserum

Conjugation

Unconjugated

RRID

AB_370194

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ubiquitin protein ligase E3A , ANCR , AS , E6-AP , EPVE6AP , HPVE6A

Cellular Localization

Cytoplasm , Nucleus

Background

This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-UBE3A antibody used in Immunohistochemistry (IHC). GTX70169

GTX70169 IHC Image

REFERENCE

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REVIEW

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Package List Price ($)
$ 399