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Utrophin antibody [DRP3/20C5]

Anti-Utrophin antibody [DRP3/20C5] used in IHC (Frozen sections) (IHC-Fr). GTX01977

Cat. No. GTX01977

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 DRP3/20C5

Isotype

 IgG1

Application

 IHC-Fr

Reactivity

 Human, Rat, Dog
Package
500 μl ($399)
See all Utrophin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr 1:2–1:10

Note :

IHC-Fr
Freeze specimen tissue blocks in isopentane chilled in liquid nitrogen.
Not tested in other applications.

Calculated MW

394 kDa. ( Note )

Product Note

This antibody recognizes amino terminal domain of the human homolog of human dystrophin, utrophin.

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Fusion protein containing the first 261 amino acids of the published DMDL gene sequence.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

utrophin , DMDL , DRP , DRP1

Cellular Localization

Cytoplasm, cytoskeleton

Background

This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Utrophin antibody [DRP3/20C5] used in IHC (Frozen sections) (IHC-Fr). GTX01977

GTX01977 IHC-Fr Image

IHC-Fr analysis of human skeletal muscle tissue using GTX01977 Utrophin antibody [DRP3/20C5].

REFERENCE

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REVIEW

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Package List Price ($)
$ 399