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VEGF Receptor 2 (phospho Tyr1054) antibody

Orthogonal
Anti-VEGF Receptor 2 (phospho Tyr1054) antibody used in Western Blot (WB). GTX25472

Cat. No. GTX25472

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IP

Reactivity

 Human, Mouse
Package
50 μl ($399)
See all VEGF Receptor 2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.35-1.0 μg/ml
IP Assay dependent
Not tested in other applications.

PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 1mg/ml BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic phosphopeptide from human VEGFR2 containing tyrosine 1054. The sequence is conserved in mouse and rat.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

kinase insert domain protein receptor , 6130401C07 , Flk-1 , Flk1 , Krd-1 , Ly73 , VEGFR-2 , VEGFR2 , orv , sVEGFR-2

Background

Vascular endothelial growth factor receptor 2 (VEGFR 2, also known as KDR / FLK 1) is a 200 kDa member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGFR 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2- and phosphotyrosine binding containing signaling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGFR 2 and its intrinsic tyrosine kinase activity.

Database

Research Area

DATA IMAGES

Anti-VEGF Receptor 2 (phospho Tyr1054) antibody used in Western Blot (WB). GTX25472

GTX25472 WB Image

Orthogonal

WB analysis of PAE cells transfected with a chimeric receptor and stimulated with CSF (Lane 1-4) or from NIH3T3 cells transfected with human VEGFR2 left unstimulated (Lane 5) or stimulated with VEGF (Lane 6) using GTX25472 VEGF Receptor 2 (phospho Tyr1054) antibody.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399