GeneTex
United States (US)

VEGFD recombinant protein

Cat No. GTX65092

Application ELISA, Functional Assay, Apuri, Blocking
Reactivity Human
Species Human
PROPERTIES

Form

Lyophilized powder

Storage

Reconstitute in ddH₂O. Stored at -20ºC for future use.

Antigen Species

Human

Expression System

E. coli

Purification


Purity was assessed by SDS-PAGE (≥98%) and by HPLC.

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Vascular Endothelial Growth Factor D,Figf,Vegf-D,Vegfd

Background

VEGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. In adult human tissues, VEGF-D mRNA is most abundant in heart, lung, skeletal muscle, colon, and small intestine. Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors. However, VEGF-D does not bind to VEGFR-1. Expression of a truncated derivative of VEGF-D demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other VEGF family members and that corresponds to the mature form of VEGF-C. In addition, VEGF-D is a mitogen for endothelial cells. Recombinant VEGF-D was expressed based on sequence from Genebank Accession# D89630, 20-354 aa.

Research Area