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p38 MAPK antibody [RM245]

Anti-p38 MAPK antibody [RM245] used in Western Blot (WB). GTX33621
Anti-p38 MAPK antibody [RM245] used in IHC (Paraffin sections) (IHC-P). GTX33621

Cat. No. GTX33621

Reference 1

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 RM245

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μl ($399)
See all p38 MAPK products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000 - 1:2000
IHC-P 1:1000 - 1:5000
Not tested in other applications.

Calculated MW

41 kDa. ( Note )

Predict Reactivity

Mouse, Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 50% Glycerol

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A peptide corresponding to human p38 MAPK.

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CSBP,CSBP1,CSBP2,CSPB1,EXIP,MAPK14,Mxi2,PRKM14,PRKM15,RK,SAPK2A,mitogenactivated protein kinase 14,p38,p38ALPHA,p38 MAPK,p38 alpha,mitogen-activated protein kinase 14

Cellular Localization

Cytoplasm,Nucleus

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-p38 MAPK antibody [RM245] used in Western Blot (WB). GTX33621

GTX33621 WB Image

WB analysis of HeLa cell lysate using GTX33621 p38 MAPK antibody [RM245].
Dilution : 1:1000

Anti-p38 MAPK antibody [RM245] used in IHC (Paraffin sections) (IHC-P). GTX33621

GTX33621 IHC-P Image

IHC-P analysis of human breast cancer tissue using GTX33621 p38 MAPK antibody [RM245].
Dilution : 1:5000

REFERENCE

Application Reference

Dom?nguez-Mart?nez DA et al. Viruses 2023; 15 (3) IL-8 Secreted by Gastric Epithelial Cells Infected with Helicobacter pylori CagA Positive Strains Is a Chemoattractant for Epstein-Barr Virus Infected B Lymphocytes.
Application : WB
Reactivity : Human
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REVIEW

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Package List Price ($)
$ 399