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p53 antibody [DO-7] (ready-to-use)

Anti-p53 antibody [DO-7] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX20911
Anti-p53 antibody [DO-7] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX20911
Anti-p53 antibody [DO-7] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX20911

Cat. No. GTX20911

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 DO-7

Isotype

 IgG2b

Application

 IHC-P

Reactivity

 Human
Package
6 ml ($399)
See all p53 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P Assay dependent

Note :

IHC-P
Recommendations for antigen retrieval : Citrate Buffer pH 6.0 at room temperature for 30 mins.
Not tested in other applications.

Calculated MW

44 kDa. ( Note )

Product Note

This antibody reacts with wild as well as mutant types of P53 protein. It recognizes an epitope in the N-terminus of p53 protein, known to reside between amino acids 35 to 45.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human wild type P53 protein expressed in E. coli.

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tumor protein p53 , BCC7 , BMFS5 , LFS1 , P53 , TRP53

Cellular Localization

Cytoplasm , Nucleus , Endoplasmic reticulum , Mitochondrion matrix

Background

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Database

Research Area

DATA IMAGES

Anti-p53 antibody [DO-7] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX20911

GTX20911 IHC-P Image

IHC-P analysis of human colon adenocarcinoma tissue using GTX20911 p53 antibody [DO-7] (ready-to-use) with GTX03608 Quatro Sol I 10X Citrate Buffer pH6.0 Kit.

Anti-p53 antibody [DO-7] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX20911

GTX20911 IHC-P Image

IHC-P analysis of human colon adenocarcinoma tissue using GTX20911 p53 antibody [DO-7] (ready-to-use) with GTX03609 Quatro Sol II 10X Tris-EDTA Buffer pH9.0 Kit.

Anti-p53 antibody [DO-7] (ready-to-use) used in IHC (Paraffin sections) (IHC-P). GTX20911

GTX20911 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX20911 p53 antibody [DO-7] (ready-to-use).

REFERENCE

Clone Reference

Wu CE et al. Am J Cancer Res 2022; 12 (9):4399-4410 In vitro and in vivo study of GSK2830371 and RG7388 combination in liver adenocarcinoma.
Chiao-En Wu et al. Cancers (Basel) 2021; 13 (15) WIP1 Inhibition by GSK2830371 Potentiates HDM201 through Enhanced p53 Phosphorylation and Activation in Liver Adenocarcinoma Cells.
Submit a Reference

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399