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pan Cytokeratin antibody [PCK-26] (FITC)

Cat. No. GTX11214

Reference 6

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 PCK-26

Isotype

 IgG1

Application

 IHC-P, IHC-Fr

Reactivity

 Human, Mouse, Rat, Rabbit, Goat, Sheep, Bovine, Cat, Dog, Hamster, Chicken, Guinea pig, Pig, Carp, Lizard, Snake
Package
100 μl ($399)
See all pan Cytokeratin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:25
IHC-Fr Assay dependent
Not tested in other applications.

Product Note

The antibody recognizes an epitope located on the Type II cytokeratins 1, 5, 6, and 8. PCK-26 is a broad spectrum antibody which reacts specifically with a variety of normal, reactive, and neoplastic epithelial tissues. The antibody reacts with simple, cornifying, and non-cornifying squamous epithelia and pseudostratified epithelia.

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Protect from light.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

cytokeratin from human epidermis.

Purification

Purified immunoglobulin

Conjugation

Fluorescein isothiocyanate (FITC)

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Background

GT211214 may be used for the localization of cytokeratins using various immunochemical assays including direct immunofluorescence using frozen or fixed tissue sections or cultured cells. It may also be used in flow cytometry of normal and neoplastic epithelial cells. Intermediate-sized filaments are abundant cytoplasmic structural proteins in most vertebrate cells.

Research Area

REFERENCE

Clone Reference

Nat Genet . 2023; Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis
Campello E et al. Liver Int 2019; (Epub) Changes in plasma circulating microvesicles in patients with HCV-related cirrhosis after treatment with direct-acting antivirals.
Meyer N et al. Sci Rep 2017; 7:45106 Chymase-producing cells of the innate immune system are required for decidual vascular remodeling and fetal growth.
Henderson SE et al. Neoplasia 2016; 18 (12):765-774 Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42.
Deshpande P et al. Burns 2013; 39 (6):1170-7 The use of allodermis prepared from Euro skin bank to prepare autologous tissue engineered skin for clinical use.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399