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United States (US)

GFR alpha 3 peptide

Cat. No. GTX26100

Application

 Neutralizing/Inhibition

Species

 Human
Package
50 μg ($139)
See all GFR alpha 3 products

APPLICATION

Application Note

The peptide is used for blocking the activity of anti-GFRa-3 (cat. no 8028). Incubating the peptide with equal volume of antibody for 30 min at 37ºC usually completely blocks the antibody activity in Western blotting.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.02% Sodium azide

Storage

Store the peptide at -20ºC, stable for one year.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Glial Cell Line Derived Neurotrophic Factor Family Receptor Alpha 3 , Gfralpha3 , Y15110 , Gfra3

Background

Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novelglycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb. Following the discovery of GFRa-1 and -2, a novel receptor in GFRa family was identified recently in human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 139