APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1/500 - 1/2000 |
1/200 - 1/1000 |
1/10000 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
Ascites
Preservative
0.03% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Antigen Species
Human
Immunogen
Purified recombinant fragment of MLL (aa3751-3968) expressed in E. Coli.
Purification
Unpurified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
lysine methyltransferase 2A , ALL-1 , CXXC7 , HRX , HTRX1 , MLL , MLL1 , MLL1A , TRX1 , WDSTS
Cellular Localization
Nucleus
Background
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
Database
Research Area
DATA IMAGES
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GTX83091 WB Image
WB analysis of truncated MLL recombinant protein (1) andtruncated GFP-MLL(aa3714-3969) transfected Cos7 cell lysate (2) using GTX83091 MLL antibody [10F8D7].
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GTX83091 IHC-P Image
IHC-P analysis of human lung cancer (left) and esophagus cancer (right) using GTX83091 MLL antibody [10F8D7].
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REFERENCE
There are currently no references for MLL antibody [10F8D7] (GTX83091). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for MLL antibody [10F8D7] (GTX83091). Be the first to share your experience with this product.