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alpha Smooth Muscle Actin antibody [αsm-1]

Anti-alpha Smooth Muscle Actin antibody [αsm-1] used in IHC (Paraffin sections) (IHC-P). GTX44499

Cat. No. GTX44499

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 αsm-1

Isotype

 IgG2a

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($479)
See all alpha Smooth Muscle Actin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:50

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections.
Not tested in other applications.

Calculated MW

42 kDa. ( Note )

Product Note

Reactive with smooth muscle cells in blood vessel walls, gut wall, myometrium and arrectores pili of skin. Myoepithelial cells such as those in breast and salivary gland also contain actin.

PROPERTIES

Form

Liquid

Buffer

PBS pH7.6, 1% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

>4.5 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic amino terminal decapeptide of alpha smooth muscle isoform of actin.

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

actin alpha 2, smooth muscle , ACTSA

Cellular Localization

Cytoplasm, cytoskeleton

Background

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]

Database

  • Gene ID: 59 ACTA2
  • UniProt: P62736 ACTA2

Research Area

DATA IMAGES

Anti-alpha Smooth Muscle Actin antibody [αsm-1] used in IHC (Paraffin sections) (IHC-P). GTX44499

GTX44499 IHC-P Image

IHC-P analysis of human small bowel tissue using GTX44499 alpha Smooth Muscle Actin antibody [αsm-1]. Note cytoplasmic staining of the muscularis mucosa, vascular walls and smooth muscle fibers in the lamina propria.

REFERENCE

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REVIEW

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Package List Price ($)
$ 479