GeneTex's KO-Validated RGS4 Recombinant Monoclonal Antibody

16-Aug-2023

Regulator of G-protein signaling 4 (RGS4) belongs to the structurally smallest (i.e., B/R4) family of G protein GTPase-activating proteins (GAPs) in the RGS superfamily. RGS proteins modulate a plethora of G protein-coupled receptor (GPCR)-triggered signaling cascades via their GAP function on G protein α subunits, essentially increasing their GTPase activity to convert Gα proteins into their inactive GDP-bound form. RGS4 is expressed primarily in the nervous system and heart, and is linked to several neuronal GPCR pathways (1). Recent studies have also revealed RGS4 to be a potential therapeutic target for both human heart failure (HF) and atrial fibrillation (AFib) (2).

GeneTex is proud to offer the newly released knockout (KO)-validated recombinant rabbit monoclonal RGS4 antibody [HL1522] (GTX636996) to detect RGS4 in several species and applications. Please see the product images below and visit www.genetex.com for more details.

RGS4 antibody [HL1522] (GTX636996)

SH-SY5Y cell wildtype (WT) and RGS4-knockout (KO) lysates demonstrate antibody specificity.

ICC/IF staining of 4% PFA-fixed SH-SY5Y cells show RGS4 expression in the cytosol.

Detection of RGS4 in paraffin-embedded mouse brain and heart tissues.

References:

Nat Rev Drug Discov. 2002 Mar;1(3):187-97. doi: 10.1038/nrd747.

Int J Mol Sci. 2023 Mar 24;24(7):6136. doi: 10.3390/ijms24076136.

GeneTex's KO-Validated RGS4 Recombinant Monoclonal Antibody

RGS4 antibody [HL1522] (GTX636996)

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