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Normal Tissue Gallery- GTX04471

Glutamine synthetase antibody [MSVA-750M] HistoMAX

 

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Adrenal gland – GS staining (variable intensity) in a fraction of cells
Aorta, media
Appendix, mucosa – GS staining predominates in macrophages and is only focal and mostly faint in epithelial cells
Appendix, mucosa – GS staining predominates in macrophages
Appendix, muscular wall
Bone marrow
Breast – A faint GS staining occurs in acinar cells of the breast
Bronchus, mucosa – A fraction of cells of the respiratory epithelium show a moderate GS staining
Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter) – An intense GS positivity occurs in glia cells and in associated fibres. Purkinje cells are GS negative.
Cerebellum (molecular layer, Purkinje cell layer, granule cell layer, white matter) – Intense GS positivity of glia cells
Cerebrum, grey matter – An intense GS positivity is seen in all glia cells and in associated fibres. Neurons are GS negative
Cerebrum, white matter – All glia cells show strong GS positivity
Colon descendens, mucosa – GS staining predominates in macrophages and is only faint in some epithelial cells
Colon descendens, muscular wall
Duodenum, Brunner gland
Duodenum, mucosa – GS staining predominates in macrophages and is only focal and faint in epithelial cells
Epididymis – Focal GS staining of moderate intensity in the corpus
Epididymis – GS staining is absent in this sample of the corpus
Epididymis – Strong GS staining in most epithelial cells of the cauda epididymis
Esophagus, squamous epithelium – A moderate to strong nuclear and cytoplasmic GS staining occurs in the basal and suprabasal cell layers as well as in the top cell layers of the squamous epithelium.
Fallopian tube, mucosa – A fraction of epithelial cells shows a weak to moderate staining
Fat
Gallbladder, epithelium – GS staining is focal and faint in epithelial cells
Heart muscle
Ileum, mucosa – GS staining predominates in macrophages
Kidney pelvis (urothelium) – GS staining is largely absent in the urothelium
Kidney, cortex – Few distal tubuli or collecting ducts may show GS staining
Kidney, medulla
Liver – A weak GS staining is seen in Kupffer cells
Liver – GS staining is strong in centrilobular hepatocytes, weak to moderate in Kupffer cells but absent in periportal hepatocytes
Liver – GS staining is weak in Kupffer cells but absent in periportal hepatocytes and bile ducts
Lung – GS staining is limited to macrophages
Lymph node – GS staining of weak to moderate intensity occurs in sinus macrophages, dendritic cells, and in endothelial cells of small capillaries
Lymph node – Strong GS staining of dendritic cells in a germinal centre
Ovary, corpus luteum – GS staining is variable and ranges from weak to strong (mosaic pattern)
Ovary, stroma
Pancreas – A weak to moderate GS staining is focally observed in acinar cells, intercalated ducts and excretory ducts while islet cells are negative
Parathyroid gland
Parotid gland – Weak GS staining of excretory ducts but moderate to strong positivity of fat cells
Pituitary gland, anterior lobe – A weak to moderate GS staining can occur in few cells of the adenohypophysis
Pituitary gland, anterior lobe – GS positive cells are not always seen in samples from the adenohypophysis
Pituitary gland, posterior lobe – Intense GS positivity of glia cells and associated fibres
Placenta (amnion and chorion) – Chorion and amnion cells are negative but some decidua cells show a weak to moderate GS staining
Placenta, early
Placenta, mature
Prostate
Rectum, mucosa – GS staining of macrophages
Seminal vesicle – GS staining of variable intensity occurs in a fraction of epithelial cells
Sinus paranasales – Most cells of the respiratory epithelium and of associated glands show a moderate to strong GS staining
Skeletal muscle – A weak GS staining is seen in satellite cells of skeletal muscle
Skin – A nuclear and cytoplasmic GS staining can be seen in the lower third and in the top layers of the squamous epithelium
Skin (anal canal) – A nuclear and cytoplasmic GS staining is seen in the top third of the squamous epithelium
Spleen – Weak to moderate GS staining in histiocytic cells and granulocytes
Stomach, antrum
Stomach, corpus – A strong GS staining is seen in glandular cells while staining is only weak in surface epithelial cells
Sublingual gland – Strong GS staining of myoepithelial cells
Testis – GS staining is weak to moderate in Sertoli cells and strong and Leydig cells
Thymus – Prominent GS staining of macrophages and dendritic cells
Thyroid gland – Strong GS staining in follicle cells of the thyroid
Tonsil – GS staining of macrophages and of a fraction of squamous epithelial cells of a crypt
Tonsil, surface epithelium – A nuclear and cytoplasmic GS staining is preferentially seen in the top third of the squamous epithelium. Some basal and intermediary cells do also stain.
Urinary bladder, muscular wall
Urinary bladder, urothelium – A strong nuclear and cytoplasmic GS staining occurs in the urothelium. Staining is weakest in basal and umbrella cells
Uterus, ectocervix – A nuclear and cytoplasmic GS staining is seen in the top third of the squamous epithelium
Uterus, ectocervix – A nuclear and cytoplasmic GS staining occurs in the top third of the squamous epithelium
Uterus, endocervix
Uterus, endometrium (pregnancy) – GS staining is very intense in decidua cells
Uterus, endometrium (proliferation)
Uterus, endometrium (secretion) – GS staining predominates in stromal and inflammatory cells and is only focal and faint in epithelial cells
Uterus, myometrium – A weak GS staining is seen in few endothelial cells of small capillaries
   

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