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AMACR antibody

Cat No. GTX15893

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IM
Reactivity Human, Mouse, Rat
Package
100 μg ($329)
APPLICATION

Application Note

IM: Use at an assay dependent dilution. WB: Use at a dilution of 1/500. GTX15893 strongly labels bands at 32 and 42 kDa corresponding to AMCR I and II variants. Does not work well with IHC. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

42 kDa. ( Note )
PROPERTIES

Form

Liquid

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.75 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: GAAVLRRLCKRSDVLLEPFR , corresponding to amino acids 62-81 of Human AMACR.

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Alpha-Methylacyl-Coa Racemase,Amacrd,Cbas4,P504S,Race,Rm,Amacr

Cellular Localization

Mitochondrial

Background

Alpha-methyacyl-CoA racemase (AMCR), is an enzyme invloved in beta oxidation of branched chain fatty acids and bile salt intermediates, and has recently been identified as a neomarker for prostate cancer, where it is over expressed. Several different isoforms have been reported that are produced either by extensinve alternatve splicing of 5 exons or by use of alternate initiation codons. At least 2 different transcripts, each derived from the 5 exons, have been reported, AMCR I and AMCR II. AMCR I is the most abundant form and enclodes for a 382 amino acid protein (42kDa). The other isoform AMCR II exhibits significnat homolgy to fumerate hydratase and encoes a 288 amino acid protein (32 kDa). Several other variants of IA and IIA isoforms are charcterized recently. The variants lack exon 3 and are designated as IB and IIB. In prostate tumor tissues that over express AMCR, both the A and B forms are over-expressed.

Database

Research Area

REFERENCE
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Package List Price ($)
$ 329