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ATP11A antibody

Anti-ATP11A antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85170
Anti-ATP11A antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85170
Anti-ATP11A antibody used in Western Blot (WB). GTX85170

Cat. No. GTX85170

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all ATP11A products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 μg/mL
ICC/IF 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

130 kDa. ( Note )

Positive Control

K-562 Cell Slide(GTX25535) , K562 Cell Lysate(GTX27911)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

ATP11A antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human ATP11A.The immunogen is located within the first 50 amino acids of ATP11A.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ATPase phospholipid transporting 11A , ATPIH , ATPIS

Cellular Localization

Cell membrane,Endoplasmic reticulum

Background

ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.

Database

Research Area

DATA IMAGES

Anti-ATP11A antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85170

GTX85170 ICC/IF Image

ICC/IF analysis of K562 cells using GTX85170 ATP11A antibody.
Working concentration : 10 μg/ml

Anti-ATP11A antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85170

GTX85170 ICC/IF Image

ICC/IF analysis of K562 cells using GTX85170 ATP11A antibody.
Working concentration : 20 μg/ml

Anti-ATP11A antibody used in Western Blot (WB). GTX85170

GTX85170 WB Image

WB analysis of K562 cell tissue lysate in (A) the absence and (B) the presence of blocking peptide using GTX85170 ATP11A antibody.
Working concentration : 1 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399