GeneTex
United States (US)

Aprotinin protein

Cat No. GTX65522

Application ELISA, Functional Assay, Apuri, Blocking
APPLICATION

Application Note

Protein activity determined to be 5x10^6 IU/mg.

Calculated MW

6.5 kDa. ( Note )
PROPERTIES

Form

Lyophilized powder

Storage

For long term storage, please keep at -70ºC or below. Avoid repeared freeze-thaw cycles.

Expression System

Bovine lung

Purification


Purity was assessed by SDS-PAGE (≥98%) and by HPLC (≥98%).

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Pancreatic trypsin inhibitor, BPTI, Basic protease inhibitor, AP, BPI, Aprotinin

Background

Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung, inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins. Aprotinin is a natural proteinase inhibitor polypeptide consisting of fifty-eight amino acids arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a molecular mass of 6512 Daltons. Aprotinin is purified by proprietary chromatographic techniques.
Package List Price ($)
$ 199