GeneTex
United States (US)

CD8 antibody [B334 (H030-1.2)] (FITC)

Cat No. GTX28663

Host Mouse
Clonality Monoclonal
Clone Name B334 (H030-1.2)
Isotype IgM
Application IHC-Fr
Reactivity Human
APPLICATION

Application Note

Not suitable for paraffin sections

Specificity/Sensitivity

These antibody reacts with a 32 kD molecule present on human suppressor/cytotoxic T-cells in peripheral lymphoid tissue. These antibodies also react with sinus-lining cells in the human spleen. Approximately 80% of T-cells in bone marrow and gut epithelium react with this antibody
PROPERTIES

Form

Liquid

Buffer

50 mM borate, 150 mM NaCl, BSA 2mg/mL, and 0.05% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Purification

Purified IgM

Conjugation

Fluorescein isothiocyanate (FITC)

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Cellular Localization

Cell Membrane

Background

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.

Database

Research Area

Package List Price ($)
$ 319