GeneTex
United States (US)

CX3CR1 antibody

Cat No. GTX28020

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

Western blot 1:500 - 50 kD band. Not yet tested in other applications.

Calculated MW

40 kDa. ( Note )

Positive Control

THP-1 cell lysate

Specificity/Sensitivity

This antibody recognizes human, mouse and rat CX3CR1 (50 kD).
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide, pH 7.4

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide, corresponding to amino acids 175-189 of Human CX3CR 1.

Purification

IgG fraction
Purified by immunoaffinity chroma-tography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

CMKDR1, 1524, GPR13, P49238, V28, 601470, GPRV28, CMKBRL1, CX3CR1, CCRL1, Fractalkine

Background

CX3CR1 is one of the chemokine receptors that are required as co-receptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively, (1-4). The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine (6). CX3CR1 mediates leukocyte migration and adhesion (5). CX3CR1 is expressed in a variety of human tissues and cell lines (2).

Database

Research Area

Package List Price ($)
$ 389