GeneTex
United States (US)

IL4 protein

Cat No. GTX29623

Reactivity Human
Species Human
APPLICATION

Application Note

The ED50, determined by the dose-dependent stimulation of the proliferation of human TF-1 cells, is < 0.2 ng/ml, corresponding to a specific activity of > 5 x 10^6 units/mg.
PROPERTIES

Form

Lyophilized powder

Storage

The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20 ºC. We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0mg/ml. Please prevent freeze-thaw cycles.

Antigen Species

Human

Region/Sequence

Highly pure (>98%) recombinant hIL-11 (human Interleukin-11)

Purification


Sterile filtered Greater than 98% pure by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Cellular Localization

Secreted

Background

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Research Area

Package List Price ($)
$ 299