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PLCG1 antibody

Orthogonal
Anti-PLCG1 antibody used in Western Blot (WB). GTX30787
Anti-PLCG1 antibody used in Immunoprecipitation (IP). GTX30787

Cat. No. GTX30787

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IP

Reactivity

 Human, Mouse, Rat, Monkey
Package
50 μl ($399)
See all PLCG1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000
IP 1:50
Not tested in other applications.

Calculated MW

149 kDa. ( Note )

Product Note

Does not crossreact with PLCgamma2.

PROPERTIES

Form

Liquid

Buffer

10mM HEPES, 150mM NaCl, 0.01% BSA, 50% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide corresponding to the C-terminal residues of human Phospholipase C, gamma 1 (PLCg1).

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

NCKAP3 , PLC1 , PLC148 , PLCG1 , PLCII , PLCgamma1 , phospholipase C gamma 1 , PLC gamma 1 , PLC gamma I , PLC γ1

Cellular Localization

Cell projection,Lamellipodium,Ruffle

Background

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-PLCG1 antibody used in Western Blot (WB). GTX30787

GTX30787 WB Image

Orthogonal

WB analysis of untreated or PDGF-stimulated NIH3T3 cell lysate using GTX30787 PLCG1 antibody.

Anti-PLCG1 antibody used in Immunoprecipitation (IP). GTX30787

GTX30787 IP Image

IP analysis of untreated or PDGF-stimulated NIH3T3 cell lysate using GTX30787 PLCG1 antibody.

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Package List Price ($)
$ 399