GeneTex
United States (US)

TPO recombinant protein

Cat No. GTX65271

Application ELISA, Functional Assay, Apuri, Blocking
Reactivity Human
Species Human
APPLICATION

Application Note

The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found <1 ng/ml, corresponding to a specific activity of >1x10^6 IU/mg.
PROPERTIES

Form

Lyophilized powder

Antigen Species

Human

Expression System

E. coli

Purification


Purity was assessed by SDS-PAGE (≥98%) and by HPLC (≥98%).

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Megakaryocyte growth and development facto, TPO, Megakaryocyte colony-stimulating factor, Cmpl ligand, MPLLG, Megakaryocyte colonystimulating factor, Myeloproliferative leukemia virus oncogene ligand, THPO., MGC163194, C-mpl ligand, MGDF, MKCSF, C mpl ligand

Background

TPO (Thrombopoietin, also known as Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide, which contains the erythropoietin-like domain of the full length TPO protein.

Research Area

Package List Price ($)
$ 509