APPLICATION
PROPERTIES
Form
Liquid
Buffer
20mM Tris-HCl, 10% Glycerol
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Region/Sequence
Full length protein, N-terminal His-Tag; MGSSHHHHHH SSGLVPRGSH MGSMPKGKKA KGKKVAPAPA VVKKQEAKKV VNPLFEKRPK NFGIGQDIQP KRDLTRFVKW PRYIRLQRQR AILYKRLKVP PAINQFTQAL DRQTATQLLK LAHKYRPETK QEKKQRLLAR AEKKAAGKGD VPTKRPPVLR AGVNTVTTLV ENKKAQLVVI AHDVDPIELV VFLPALCRKM GVPYCIIKGK ARLGRLVHRK TCTTVAFTQV NSEDKGALAK LVEAIRTNYN DRYDEIRRHW GGNVLGPKSV ARIAKLEKAK AKELATKLG
Expression System
E. coli
Purity
> 85% by SDS-PAGE.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
ribosomal protein L7a , L7A , SURF3 , TRUP
Background
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX67757-pro Image
3μg Human RPL7A protein (GTX67757-pro) by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
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REFERENCE
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REVIEW
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