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New Recombinant Rabbit Interleukin-6 (IL-6) Monoclonal Antibody

 

Interleukin-6 (IL-6) is a cytokine with a high clinical profile due to its involvement in inflammatory processes, autoimmune disease, and cancer progression. IL-6 can interact with both soluble and transmembrane forms of the IL-6 receptor α, with binding to the soluble receptor leading to pro-inflammatory signaling while anti-inflammatory signaling follows transmembrane receptor binding (1, 2). Specific targeting of IL-6-dependent pro-inflammatory events, a major focus of therapeutics development, will be greatly accelerated with better understanding of the underlying mechanistic features of IL-6 biology.

GeneTex has introduced a new recombinant rabbit monoclonal IL-6 antibody with high specificity and sensitivity to its catalog of conventional mouse monoclonal and rabbit polyclonal IL-6 reagents. Matched sandwich ELISA (sELISA) pairs (see below) using this rabbit monoclonal antibody in combination with different mouse monoclonal antibodies allow detection of human IL-6. In addition, GeneTex offers recombinant human IL-6 protein (GTX135982-pro & GTX135983-pro) in two useful formats. Please review the products below and go to www.genetex.com to learn more.

 

Matched IL-6 sELISA Antibody Pairs

Recombinant

IL-6 antibody [HL1168] (GTX636473)

Capture Antibody:
IL-6 antibody [GT1535] (GTX636571)

Detection Antibody:
IL-6 antibody [HL1168] (GTX636473)

Sample:
Recombinant Human IL-6 protein, His tag (GTX135982-pro)
Recombinant
IL-6 antibody [HL1168] (GTX636473)

Capture Antibody:
IL-6 antibody [GT519-1] (GTX636573)

Detection Antibody:
IL-6 antibody [HL1168] (GTX636473)

Sample:
Recombinant Human IL-6 protein, His tag (GTX135982-pro)
Recombinant
   

IL-6 Recombinant Proteins

Cat. No. Product Name Expression System Applications
GTX135982-pro Human IL-6 protein, His tag HEK293 cells ELISA, Sandwich ELISA
GTX135983-pro Human IL-6 protein, mouse Fc tag HEK293 cells ELISA

 

References:

  1. Cell Commun Signal. 2019 May 17;17(1):46. doi: 10.1186/s12964-019-0356-0.
  2. Bioorg Med Chem. 2020 Mar 1;28(5):115327. doi: 10.1016/j.bmc.2020.115327.