Carbonic Anhydrase IX (CA IX): Acid-Base Regulator and Driver of Tumorigenesis

Carbonic anhydrase IX (CA IX) is a transmembrane, hypoxia-induced zinc metalloenzyme that converts carbon dioxide to bicarbonate and protons. This acid-base regulatory function is crucial for both maintaining an alkaline intracellular pH that promotes survival and growth of malignant cells while also amplifying an extracellular acidosis that facilitates their invasion and metastasis (1). Cancer cells that express CA IX often represent the most clinically aggressive components of heterogeneous tumors, making CA IX a key biomarker as well as a major therapeutic target.

GeneTex has just added a new recombinant rabbit monoclonal antibody to its catalog of CA IX reagents as part of its comprehensive portfolio of products for hypoxia and cancer research. Please see the highlighted products below and visit www.genetex.com for additional details.