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SARS-CoV-2 can infect the human brain

22-Feb-2021

 

With mass vaccination efforts underway, there is hope that the worst of the SARS-CoV-2/COVID-19 pandemic may soon be over. Nevertheless, much remains unknown about SARS-CoV-2’s effects on organ systems other than the lungs, notably the central nervous system (CNS). Though multiple studies indicate direct infection of neurons, a full understanding of the virus’s neuroinvasive capability remains elusive. This is an important issue as many COVID-19 patients continue to suffer neurological and neuropsychiatric symptoms once the acute disease resolves. In an intriguing study by Song et al., the authors use human brain organoids, a human ACE2-expressing mouse model, and brain tissue samples from COVID-19 patients as three distinct yet complementary approaches to investigate the consequences of SARS-CoV-2 infection of the brain (1). Their findings offer compelling evidence for ACE2-dependent infection of CNS neurons with subsequent viral replication and neuronal death. SARS-CoV-2 elicited transcriptional changes and a variable immune response that differed from what is observed with ZIKV, another neurotropic virus. In addition, vascular abnormalities as well as evidence of hypoxia and microinfarcts were detected in infected mouse and human brain tissue. In summary, the results of Song et al. elegantly demonstrate SARS-CoV-2’s neurotropism, establishing a basis for the development of potential interventions to ameliorate or prevent persistent CNS-related sequelae.

GeneTex is proud to offer the most comprehensive, well-validated, and widely used catalog of SARS-CoV-2 reagents, including antibodies, recombinant proteins, transfected FFPE cell blocks, and ELISA products. Two of GeneTex’s SARS-CoV-2 antibodies (GTX635679 and GTX632604) were used in the Song et al. study, as was GeneTex’s widely published HIF-1alpha antibody (GTX127309). For more information, please see the images below and click on the links.

See All Reagents for COVID-19 Research

 

See All Reagents for Neuroscience Research

 

Highlighted Antibodies

Recombinant Citation-Support KOKD-Validation Comparable Abs Orthogonal Validation Protein Overexpression 
SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] (GTX632604)

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] (GTX632604)

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344] (GTX635679)

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344] (GTX635679)

HIF1 alpha antibody (GTX127309)

HIF1 alpha antibody (GTX127309)

CD31 antibody (GTX130274)

CD31 antibody (GTX130274)

Reference:

  1. J Exp Med. 2021 Mar 1;218(3):e20202135.