SARS-CoV-2 (COVID-19) Antibodies and Reagents

GeneTex continues to expand and validate its comprehensive catalog of outstanding antibodies and reagents for SARS-CoV-2 (COVID-19) research. This includes ongoing assessment of our antibodies’ ability to detect important viral variants, particularly the WHO-designated Variants of Concern (VOCs). For more information, please see Tables 1-2 below.

In GeneTex’s SARS-CoV-2 spike antibody portfolio, the anti-spike RBD [HL1014] and anti-spike S1 [HL13402] recombinant rabbit clones exhibit high affinity for all SARS-CoV-2 spike proteins, including those of the B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), and B.1.617.2 (Delta) variants (Table 1). Clone [HL13402] also performs exceptionally well when paired with the widely published mouse clone [1A9] (against the S2 subunit) for sandwich ELISA.

GeneTex’s recombinant rabbit nucleocapsid antibodies display high affinity for the WIV04/2019 (reference sequence) human cell-expressed full-length SARS-CoV-2 nucleocapsid protein, with EC50 values ranging from 0.006-0.074 nM. Importantly, one matched nucleocapsid antibody pair (i.e., GTX635689 and GTX635686) demonstrates superior sensitivity in sandwich ELISA and lateral flow assays. This pair also recognizes the nucleocapsid protein of the B.1.617.2 (Delta) variant, as do several other individual recombinant clones (Table 2).

Taken together, GeneTex’s large selection of SARS-CoV-2 antibodies virtually guarantees that you will find a reagent appropriate for your desired application.

Table 1. SARS-CoV-2 Variant Detection by GeneTex Spike Antibody Clones

Recombinant spike proteins (trimer) derived from different SARS-CoV-2 variants were assayed by indirect ELISA using the specified GeneTex monoclonal antibodies.

Table 2. SARS-CoV-2 Delta Variant Detection by GeneTex Nucleocapsid Antibody Clones

Recombinant nucleocapsid proteins derived from different SARS-CoV-2 variants were assayed by ELISA (either indirect or sandwich ELISA) using the specified GeneTex monoclonal antibodies.

Full Listing of Products for SARS-CoV-2 (COVID-19) Research

Anti-Spike Antibodies

Product Name Clonality EC50 Applications Cat. No. Spike S1 antibody [HL1] Rb recAb 117 pM WB, ICC/IF, ELISA, Sandwich ELISA GTX635656   Spike S1 antibody [HL6] Rb recAb 251 pM WB, ICC/IF, IHC-P, FACS, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635654 Spike S1 antibody [HL134] Rb recAb 552 pM WB, ICC/IF, ELISA, IHC-P (cell pellet) GTX635671 Spike S1 antibody [HL263] Rb recAb 365 pM WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635672 Spike S1 antibody [HL13402] Rb recAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX635713   Spike S1 antibody [GT263] Ms mAb   WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635708   Spike S1 antibody Rb pAb   WB, ICC/IF, ELISA GTX135384 Spike RBD antibody [HL1002] Rb recAb   ELISA, Neutralizing/Inhibition, Sandwich ELISA GTX635791 Spike RBD antibody [HL1003] Rb recAb 7.49 pM ICC/IF, ELISA, Neutralizing/Inhibition, Sandwich ELISA GTX635792 Spike RBD antibody [HL1003-HU] Hu recAb   ELISA, Neutralizing/Inhibition, Sandwich ELISA GTX635866 Spike RBD antibody [HL1004] Rb recAb 25.13 pM ICC/IF, ELISA, Neutralizing/Inhibition, Sandwich ELISA GTX635793 Spike RBD antibody [HL1004] (HRP) Rb recAb   ELISA, Sandwich ELISA GTX635793-01 Spike RBD antibody [HL1014] Rb recAb 28.77 pM ICC/IF, ELISA, Sandwich ELISA GTX635807 Spike RBD antibody [HL257] Rb recAb   WB, ICC/IF, IHC-P, ELISA, IHC-P (cell pellet) GTX635692 SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1003] (HRP) Rb recAb   ELISA, Sandwich ELISA GTX635792-01   Spike RBD antibody [GT5449] Ms mAb   WB, ELISA, Sandwich ELISA GTX636042   Spike RBD antibody Rb pAb   WB, ICC/IF, FACS, ELISA, Neutralizing/Inhibition, Sandwich ELISA, IHC-P (cell pellet) GTX135709   Spike RBD antibody Rb pAb   WB, ICC/IF GTX135385 Spike S2 antibody [HL237] Rb recAb   WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635693 Spike S2 antibody [HL1038] Rb recAb   WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635910   Spike S2 antibody [GT745] Ms mAb   WB, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX636037   Spike S2 antibody [GT8110] Ms mAb   WB, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX636038 Spike S2 / S2' antibody [HL1039] Rb recAb   WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635911   Spike S2 / S2' antibody Rb pAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX135386 Spike antibody [1A9] Ms mAb   WB, ICC/IF, IHC-P, FACS, IP, ELISA, EM, Sandwich ELISA, IHC-P (cell pellet) GTX632604 Spike antibody Rb pAb   WB, ICC/IF, IHC-P, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX135356 Spike antibody Rb pAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX135360 Spike antibody [CR3022] Hu recAb   ELISA, Neutralizing/Inhibition GTX01555 Spike antibody [CR3022-RB] Rb recAb   ELISA, Neutralizing/Inhibition GTX01556   Spike (N439K Mutant) antibody Rb pAb   WB GTX135961   Spike (A222V Mutant) antibody Rb pAb   WB GTX135960

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Anti-Nucleocapsid Antibodies

Product Name Clonality EC50 Applications Cat. No.   Nucleocapsid antibody [HL455-MS] Ms mAb   WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635712 Nucleocapsid antibody [HL5410] Rb recAb 9 pM WB, ICC/IF, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet) GTX635685 Nucleocapsid antibody [HL5410] (Gold) Rb recAb   Immunoassay GTX635685-17   Nucleocapsid antibody [HL5511] Rb recAb 14 pM WB, ICC/IF, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet) GTX635689 Nucleocapsid antibody [HL146] Rb recAb 50 pM WB, ICC/IF, ELISA, Sandwich ELISA GTX635680 Nucleocapsid antibody [HL249] Rb recAb 16 pM WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635678 Nucleocapsid antibody [HL344] Rb recAb 74 pM WB, ICC/IF, IHC-P, IHC-Fr, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635679 Nucleocapsid antibody [HL448] Rb recAb 11 pM WB, ICC/IF, IHC-P, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet) GTX635686 Nucleocapsid antibody [HL448] (HRP) Rb recAb   WB, ELISA, Sandwich ELISA GTX635686-01 Nucleocapsid antibody [HL453] Rb recAb 6 pM WB, ICC/IF, ELISA, IHC-P (cell pellet) GTX635687 Nucleocapsid antibody [HL455] Rb recAb 6 pM WB, ICC/IF, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet) GTX635688   Nucleocapsid antibody [GT113] Ms mAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX635808   Nucleocapsid antibody [6H3] Ms mAb   WB, ICC/IF, IHC-P, IP, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX632269   Nucleocapsid antibody Rb pAb   WB, ICC/IF, IHC-P, FACS, IP, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX135357 Nucleocapsid antibody Rb pAb   WB, IHC-P, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX135361   Nucleocapsid antibody Rb pAb   WB, IHC-P (cell pellet) GTX135570

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Other SARS-CoV-2 Antibodies

Product Name Clonality Applications Cat. No.   Envelop antibody Rb pAb WB GTX136046   RdRp (nsp12) antibody Rb pAb WB, ICC/IF GTX135467   RdRp (nsp12) antibody Rb pAb WB GTX135469   3CLpro (nsp5) antibody Rb pAb WB GTX135470   3CLpro (nsp5) antibody Rb pAb WB GTX135648   ORF8 antibody Rb pAb WB, ICC/IF, IHC-P (cell pellet) GTX135591   nsp1 antibody Rb pAb WB, ICC/IF GTX135586   nsp1 antibody Rb pAb WB, ICC/IF, IHC-P (cell pellet) GTX135612   nsp2 antibody Rb pAb WB, ICC/IF GTX135717   nsp3 / PL-pro antibody Rb pAb WB GTX135796 nsp3 antibody Rb pAb WB, ICC/IF, IHC-P (cell pellet) GTX135589 nsp3 antibody Rb pAb WB, ICC/IF GTX135614   nsp7 antibody Rb pAb WB GTX135728 ORF7a antibody [3C9] Ms mAb WB, ICC/IF GTX632602 nsp8 antibody [5A10] Ms mAb WB, ICC/IF, FACS GTX632696   nsp8 antibody Rb pAb WB, IHC-P (cell pellet) GTX135729   nsp8 antibody Rb pAb WB, ICC/IF, IHC-P (cell pellet) GTX135730   nsp9 antibody Rb pAb WB, ICC/IF GTX135731   nsp9 antibody Rb pAb WB, ICC/IF, IHC-P (cell pellet) GTX135732   nsp10 antibody Rb pAb WB, ICC/IF, IHC-P (cell pellet) GTX135733   nsp10 antibody Rb pAb WB, ICC/IF GTX135734   nsp15 antibody Rb pAb WB, ICC/IF GTX135737   nsp15 antibody Rb pAb WB, ICC/IF GTX135738   nsp11 antibody Rb pAb WB, ICC/IF GTX135742

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ELISA Antibody Pairs

Product Name Sensitivity Cat. No.   Spike RBD ELISA Pair [HL1014 / HL1003]   GTX500046   Spike RBD ELISA pair [HL1014/HL1004]   GTX500047   Spike ELISA Pair [1A9 / HL263]   GTX500041   Spike ELISA Pair [1A9 / HL13402]   GTX500043   Spike ELISA pair [1A9 / HL1003]   GTX500048   Nucleocapsid ELISA Pair [HL5511 / HL448] 39.06 pg/mL GTX500045 Nucleocapsid ELISA Pair [HL5410 / HL455-MS] 2.68 pg/mL GTX500042

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SARS-CoV-2 ELISA Kit

Product Name Sensitivity Applications Cat. No. SARS-CoV-2 (COVID-19) Spike-ACE2 Binding / Neutralization Assay Kit N/A Neutralizing/Inhibition GTX536401   Nucleocapsid Protein Sandwich ELISA Kit 18 pg/ml ELISA, Sandwich ELISA GTX535824   SARS-CoV-2 (COVID-19) Spike RBD Protein Sandwich ELISA Kit 1.8 pg/ml ELISA, Sandwich ELISA GTX536267

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Lateral Flow Assay (Recommended Antibody Pairs)

Antibody Pair   Product Name Clonality EC50 Cat. No. Pair I   Nucleocapsid antibody [HL5511] Rb recAb 14 pM GTX635689 Nucleocapsid antibody [HL448] Rb recAb 11 pM GTX635686 Pair II Nucleocapsid antibody [HL5410] Rb recAb 9 pM GTX635685 Nucleocapsid antibody [HL455] Rb recAb 6 pM GTX635688

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Recombinant Proteins

Product Name Expression System Applications Cat. No. Spike (ECD) protein, His tag (active) HEK293 ELISA, Sandwich ELISA, Functional Assay GTX135972-pro   Spike (D614G Mutant) protein (ECD), His tag (active) HEK293 ELISA, Functional Assay GTX02575-pro   Spike (ECD) Protein, B.1.1.7 / Alpha variant, His tag (active) HEK293 Functional Assay GTX136059-pro   Spike (ECD) Protein, B.1.351 / Beta variant, His tag (active) HEK293 ELISA, Functional Assay GTX136061-pro   Spike (ECD) Protein, P.1 / Gamma variant, His tag (active) HEK293 ELISA, Functional Assay GTX136091-pro   Spike (ECD) Protein, B.1.617.2 / Delta variant, His tag (active) HEK293 ELISA, Sandwich ELISA, Functional Assay GTX136432-pro   Spike S1 Protein, B.1.1.7 / Alpha variant, His tag (active) HEK293 Functional Assay GTX136085-pro   Spike S1 Protein, P.1 / Gamma variant, His tag (active) HEK293 Functional Assay GTX136094-pro   Spike S1 Protein, B.1.351 / Beta variant, His tag (active) HEK293 Functional Assay GTX136095-pro   Spike S1 protein, His and Avi tag (active) HEK293 ELISA, Functional Assay GTX01548-pro   Spike S1 protein, His tag (active) HEK293 ELISA, Sandwich ELISA, Functional Assay GTX135817-pro   Spike S2 (ECD) protein, mouse IgG Fc tag HEK293 ELISA, Sandwich ELISA GTX135684-pro   Spike S2 (ECD) protein, human IgG Fc tag HEK293 ELISA, Sandwich ELISA GTX01559-pro   Spike S2 Protein, B.1.1.7 / Alpha variant, His tag HEK293 ELISA, Sandwich ELISA GTX136023-pro   Spike RBD Protein, B.1.1.7 with E484K, His tag (active) HEK293 Functional Assay GTX136058-pro   Spike RBD Protein, B.1.1.7 / Alpha variant, His tag (active) HEK293 ELISA, Sandwich ELISA, Functional Assay GTX136014-pro   Spike RBD Protein, B.1.1.7 / Alpha variant, mouse Fc tag (active) HEK293 ELISA, Functional Assay GTX136024-pro   Spike RBD Protein, B.1.351 / Beta variant, His tag (active) HEK293 ELISA, Sandwich ELISA, Functional Assay GTX136022-pro   Spike RBD Protein, P.1 / Gamma variant, His tag (active) HEK293 Functional Assay GTX136043-pro   Spike RBD Protein, B.1.617.2 / Delta variant, His tag (active) HEK293 ELISA, Functional Assay GTX136332-pro   Spike RBD Protein, AY.1 / Delta plus variant, His tag HEK293 Functional Assay GTX136333-pro   Spike RBD Protein, B.1.617.1 / Kappa variant, His tag (active) HEK293 ELISA, Functional Assay GTX136058-pro   Spike RBD protein, His tag (active) HEK293 ELISA, Sandwich ELISA, Functional Assay GTX136090-pro   Nucleocapsid protein, His tag E. coli ELISA, Sandwich ELISA GTX135357-pro Nucleocapsid protein, His tag HEK293 ELISA, Sandwich ELISA GTX135592-pro   Nucleocapsid protein,His tag (Gold) HEK293 Immunoassay GTX135746-pro   Envelope protein, His and Avi tag E. coli   GTX01547-pro   Envelope Protein, GST and His Tag HEK293   GTX01565-pro   3CLpro (nsp5) protein, His tag E. coli   GTX135648-pro   3CLpro (nsp5) protein, His and Avi tag E. coli   GTX01557-pro

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Cell Pellet Blocks / Slides

Product Name Applications Cat. No. Spike FFPE 293T cell pellet block IHC-P, IHC-P (cell pellet) GTX435640   Spike S1 FFPE 293T cell pellet block IHC-P (cell pellet) GTX435643   Spike S2 FFPE 293T cell pellet block IHC-P (cell pellet) GTX435644 Nucleocapsid FFPE 293T cell pellet block IHC-P, IHC-P (cell pellet) GTX435641   Envelope FFPE 293T cell pellet block IHC-P (cell pellet) GTX435642   Membrane FFPE 293T cell pellet block IHC-P (cell pellet) GTX435645   Spike FFPE 293T cell pellet slide IHC-P (cell pellet) GTX435744

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Overexpression Lysates

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Products for Host Cell Entry Research

Product Name Clonality or Expression System Applications Cat. No.   ACE2 antibody [GT19410] Ms mAb WB, IHC-P, ELISA, Sandwich ELISA GTX635897    ACE2 antibody [N1N2], N-term Rb pAb WB, ICC/IF, IHC-P, FACS, ELISA GTX101395    ACE2 antibody [SN0754] Rb recAb WB, ICC/IF, IHC-P GTX01160   ACE2 antibody Rb pAb WB, ICC/IF, IHC-P, ELISA GTX15349   Human ACE2(ECD) protein, mouse IgG Fc tag HEK 293 ELISA, Functional Assay GTX135683-pro   Human ACE2 protein, His and Avi tag HEK 293 ELISA, Functional Assay GTX01550-pro   TMPRSS2 antibody [N2C3] Rb pAb WB, IHC-P GTX100743   Camostat mesylate   TMPRSS2 inhibitor GTX01523

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Featured Antibodies

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9]  (GTX632604)

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344]  (GTX635679)

SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1003] (GTX635792)

SARS-CoV-2 (COVID-19) Spike S1 antibody [HL13402] (GTX635713)

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ELISA Kits and Pairs 

Nucleocapsid Protein Sandwich ELISA Kit  (GTX535824)

Spike RBD ELISA pair [HL1014/HL1004] (GTX500047)

Spike RBD ELISA Pair [HL1014 / HL1003] (GTX500046)

Spike ELISA Pair [1A9 / HL13402] (GTX500043)

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Highlighted Proteins 

SARS-CoV-2 (COVID-19) Spike (ECD) protein, His tag (active) (GTX135972-pro)

SARS-CoV-2 (COVID-19) Spike RBD (K417N, E484K, N501Y Mutant) protein, His tag (active) (GTX136022-pro)

SARS-CoV-2 (COVID-19) Spike RBD (N501Y Mutant) protein, His tag (active) (GTX136014-pro)

SARS-CoV-2 (COVID-19) Spike RBD (K417T, E484K, N501Y Mutant) protein, His tag (GTX136043-pro)

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