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Recombinant Antibodies for SARS-CoV-2 Research

27-May-2020
Recombinant Antibodies for SARS-CoV-2 Research

 

GeneTex has augmented its extensive catalog of SARS-CoV-2-related antibodies and reagents with the production of recombinant antibodies targeting the viral spike and nucleocapsid proteins. The spike S1 recombinant antibodies demonstrate specificity for SARS-CoV-2 S1 with no cross-reactivity to SARS-CoV or MERS-CoV spike proteins. Clones [HL1] and [HL6] in particular exhibit high affinity for mammalian-expressed SARS-CoV-2 spike protein with EC50 values of 0.117 nM and 0.251 nM, respectively. Importantly, both antibodies perform exceptionally well when paired with GeneTex’s mouse monoclonal SARS-CoV antibody [1A9] for sandwich ELISA assays. Though there can be high homology among various regions of different coronavirus nucleocapsid proteins, GeneTex’s SARS-CoV-2 nucleocapsid antibody [HL344] is specific for SARS-CoV-2 with no cross-reactivity to MERS-CoV or SARS-CoV nucleocapsid. All eight recombinant nucleocapsid clones display high affinity for mammalian-expressed full-length SARS-Cov-2 nucleocapsid protein (EC50 values ranging from 0.006-0.074 nM), among which a SARS-CoV-2 nucleocapsid recombinant antibody pair (GTX635685; GTX635712) designed for sandwich ELISA (sELISA; GTX500042) reaching a superior sensitivity of ~3 pg/mL of recombinant nucleocapsid protein.

SARS-CoV-2 spike protein / Nucleocapsid protein

 

Highlighted ELISA Pairs

SARS-CoV-2 (COVID-19) Nucleocapsid ELISA Pair [HL5410 / HL455-MS]

SARS-CoV-2 (COVID-19) Nucleocapsid ELISA Pair [HL5410 / HL455-MS] (GTX500042)

SARS-CoV-2 (COVID-19) Spike ELISA Pair [1A9 / HL6]

SARS-CoV-2 (COVID-19) Spike ELISA Pair [1A9 / HL6] (GTX500040)

SARS-CoV-2 (COVID-19) Spike ELISA Pair [1A9 / HL263]

SARS-CoV-2 (COVID-19) Spike ELISA Pair [1A9 / HL263] (GTX500041)

SARS-CoV-2 (COVID-19) Spike ELISA Pair [1A9 / HL13402]

SARS-CoV-2 (COVID-19) Spike ELISA Pair [1A9 / HL13402] (GTX500043)

 

Featured Antibodies

Recombinant Citation-Support Protein Overexpression 

SARS-CoV-2 (COVID-19) Spike S1 antibody [HL6]

SARS-CoV-2 (COVID-19) Spike S1 antibody [HL6] (GTX635654)

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9]

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] (GTX632604)

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344]

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344] (GTX635679)

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL453]

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL453] (GTX635687)

 

Highlighted Proteins

SARS-CoV-2 (COVID-19) Spike S1 protein, His and Avi tag (active)

SARS-CoV-2 (COVID-19) Spike S1 protein, His and Avi tag (active) (GTX01548-pro)

SARS-CoV-2 (COVID-19) Spike RBD protein, His tag (active)

SARS-CoV-2 (COVID-19) Spike RBD protein, His tag (active) (GTX01546-pro)

SARS-CoV-2 (COVID-19) nucleocapsid protein, His tag

SARS-CoV-2 (COVID-19) nucleocapsid protein, His tag (GTX135592-pro)

SARS-CoV-2 (COVID-19) Envelope protein, His and Avi tag

SARS-CoV-2 (COVID-19) Envelope protein, His and Avi tag (GTX01547-pro)

 

Full Listing of Products for SARS-CoV-2 (COVID-19) Research

Antibodies

Clonality Cat. No. Product Name Host Applications
Recombinant GTX635656 SARS-CoV-2 (COVID-19) Spike S1 antibody [HL1] Rabbit WB, ICC/IF, ELISA, sELISA
GTX635671 SARS-CoV-2 (COVID-19) Spike S1 antibody [HL134] Rabbit WB, ICC/IF, ELISA
GTX635672 SARS-CoV-2 (COVID-19) Spike S1 antibody [HL263] Rabbit WB, ICC/IF, ELISA
GTX635654 SARS-CoV-2 (COVID-19) Spike S1 antibody [HL6] Rabbit WB, ICC/IF, ELISA, sELISA
GTX635713 SARS-CoV-2 (COVID-19) Spike S1 antibody [HL13402] Rabbit WB, ELISA
GTX635708 SARS-CoV-2 (COVID-19) Spike S1 antibody [GT263] Mouse WB
GTX635692 SARS-CoV-2 (COVID-19) Spike RBD antibody [HL257] Rabbit WB, ICC/IF, ELISA
GTX635693 SARS-CoV-2 (COVID-19) Spike S2 antibody [HL237] Rabbit WB, ICC/IF
GTX635680 SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL146] Rabbit WB, ICC/IF, ELISA
GTX635678 SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL249] Rabbit WB, ICC/IF, ELISA
GTX635679 SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344] Rabbit WB, ICC/IF, ELISA
GTX635685 SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL5410] Rabbit WB, ELISA, sELISA
GTX635686 SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL448] Rabbit WB, ELISA
GTX635687 SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL453] Rabbit WB, ELISA
GTX635688 SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL455] Rabbit WB, ELISA
GTX635689 SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL5511] Rabbit WB, ELISA
GTX635712 SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL455-MS] Mouse WB, ICC/IF, ELISA, sELISA
GTX01555 SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022] Human ELISA, Neutralizing/Blocking
GTX01556 SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022-RB] Rabbit ELISA, Neutralizing/Blocking
Monoclonal GTX632604 SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] Mouse WB, ICC/IF, IHC-P, FACS, IP, ELISA, sELISA
GTX632269 SARS-CoV / SARS-CoV-2 (COVID-19) nucleocapsid antibody [6H3] Mouse WB, ICC/IF, IHC-P, IP, ELISA, sELISA
GTX632602 SARS-CoV / SARS-CoV-2 (COVID-19) ORF7a antibody [3C9] Mouse WB, ICC/IF
GTX632696 SARS-CoV / SARS-CoV-2 (COVID-19) NSP8 antibody [5A10] Mouse WB
Polyclonal GTX135384 SARS-CoV-2 (COVID-19) Spike S1 antibody Rabbit WB, ICC/IF
GTX135386 SARS-CoV-2 (COVID-19) Spike S2 / S2' antibody Rabbit WB, ICC/IF, ELISA, sELISA
GTX135385 SARS-CoV-2 (COVID-19) Spike RBD antibody Rabbit WB, ICC/IF
GTX135356 SARS-CoV-2 (COVID-19) Spike antibody Rabbit WB, ICC/IF, IHC-P, ELISA
GTX135360 SARS-CoV-2 (COVID-19) Spike antibody Rabbit WB, ICC/IF, ELISA, sELISA
GTX135357 SARS-CoV-2 (COVID-19) nucleocapsid antibody Rabbit WB, ICC/IF, IHC-P, IP, ELISA, sELISA
GTX135361 SARS-CoV-2 (COVID-19) nucleocapsid antibody Rabbit WB, ICC/IF, IHC-P, ELISA, sELISA
GTX101395 ACE2 antibody [N1N2], N-term Rabbit WB, IHC-P, FACS, ELISA
GTX100743 TMPRSS2 antibody [N2C3] Rabbit WB, IHC-P

 

ELISA Pairs

Cat. No. Product Name
GTX500042 SARS-CoV-2 (COVID-19) Nucleocapsid ELISA Pair [HL5410 / HL455-MS]
GTX500041 SARS-CoV-2 (COVID-19) Spike ELISA Pair - [1A9 / HL263]
GTX500040 SARS-CoV-2 (COVID-19) Spike ELISA Pair - [1A9 / HL6]

 

Proteins

Cat. No. Product Name
GTX01554-pro SARS-CoV-2 (COVID-19) Spike S1 protein, His tag (active)
GTX01548-pro SARS-CoV-2 (COVID-19) Spike S1 protein, His and Avi tag (active)
GTX135684-pro SARS-CoV-2 (COVID-19) Spike S2 (ECD) protein, mouse IgG Fc tag
GTX01546-pro SARS-CoV-2 (COVID-19) Spike RBD protein, His tag (active)
GTX135357-pro SARS-CoV-2 (COVID-19) nucleocapsid protein, His tag
GTX135592-pro SARS-CoV-2 (COVID-19) nucleocapsid protein, His tag
GTX01547-pro SARS-CoV-2 (COVID-19) Envelope protein, His and Avi tag
GTX01565-pro SARS-CoV-2 (COVID-19) Envelope Protein, GST and His Tag
GTX135648-pro SARS-CoV-2 (COVID-19) 3C-like Proteinase protein, His tag
GTX01557-pro SARS-CoV-2 (COVID-19) 3C-like Proteinase protein, His and Avi tag

 

Cell Pellet Blocks

Cat. No. Product Name
GTX435640 SARS-CoV-2 (COVID-19) Spike FFPE 293T cell pellet block
GTX435643 SARS-CoV-2 (COVID-19) Spike S1 FFPE 293T cell pellet block
GTX435644 SARS-CoV-2 (COVID-19) Spike S2 FFPE 293T cell pellet block
GTX435641 SARS-CoV-2 (COVID-19) Nucleocapsid FFPE 293T cell pellet Block
GTX435645 SARS-CoV-2 (COVID-19) Membrane FFPE 293T cell pellet Block
GTX435642 SARS-CoV-2 (COVID-19) Envelope FFPE 293T cell pellet Block

 

Overexpression Lysates

Cat. No. Product Name
GTX535664 SARS-CoV-2 (COVID-19) Spike overexpression 293T whole cell lysate
GTX535663 SARS-CoV-2 (COVID-19) Spike S1 overexpression 293T whole cell lysate
GTX535665 SARS-CoV-2 (COVID-19) Nucleocapsid overexpression 293T whole cell lysate

 

Inhibitors

Cat. No. Product Name
GTX01523 Camostat mesylate