GeneTex offers a comprehensive catalog of outstanding antibodies and reagents for SARS-CoV-2 research. Antibody clones [HL13402], [HL1014], and [1A9] in particular exhibit high affinity for all SARS-CoV-2 spike proteins, including those of the 501Y.V1 (B.1.1.7) and 501Y.V2 (B.1.351) variants. Recombinant rabbit clone [HL13402], raised against the viral spike S1 subunit, performs exceptionally well when paired with the widely published mouse clone [1A9] (against the S2 subunit) for sandwich ELISA assays. GeneTex’s large collection of spike antibodies virtually guarantees that you will find a reagent appropriate for your desired application. Although there is high homology between different regions of the nucleocapsid proteins from MERS-CoV, SARS-CoV, and SARS-CoV-2, several of GeneTex’s SARS-CoV-2 nucleocapsid antibodies detect only SARS-CoV-2. All recombinant nucleocapsid clones display high affinity for human cell-expressed full-length SARS-CoV-2 nucleocapsid protein, with EC50 values ranging from 0.006-0.074 nM. The SARS-CoV-2 nucleocapsid recombinant antibody pair (GTX635689 and GTX635686) demonstrates superior sensitivity for sandwich ELISA and lateral flow assays. As with the spike antibody catalog, GeneTex’s extensive nucleocapsid antibody listing includes products ideal for all common applications.
GeneTex is using indirect ELISA assays to rigorously test the affinities of several of its spike antibodies for recombinant variant spike (ECD) proteins. Please see the chart below documenting current progress.
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● | Strong reaction. Defined as OD450 value >1 when 1μg/ml protein was used. | |
○ | Weak reaction. Defined as OD450 value >1 when 4μg/ml protein was used. | |
X | No reaction. Defined as OD450 value <1 when 4μg/ml protein was used. | |
N/A | Not performed. |
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