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SARS-CoV-2 (COVID-19) Antibodies and Reagents

12-Apr-2021

SARS-CoV-2 (COVID-19) Antibodies and Reagents

 

GeneTex offers a comprehensive catalog of outstanding antibodies and reagents for SARS-CoV-2 research. Antibody clones [HL13402], [HL1014], and [1A9] in particular exhibit high affinity for all SARS-CoV-2 spike proteins, including those of the 501Y.V1 (B.1.1.7) and 501Y.V2 (B.1.351) variants. Recombinant rabbit clone [HL13402], raised against the viral spike S1 subunit, performs exceptionally well when paired with the widely published mouse clone [1A9] (against the S2 subunit) for sandwich ELISA assays. GeneTex’s large collection of spike antibodies virtually guarantees that you will find a reagent appropriate for your desired application. Although there is high homology between different regions of the nucleocapsid proteins from MERS-CoV, SARS-CoV, and SARS-CoV-2, several of GeneTex’s SARS-CoV-2 nucleocapsid antibodies detect only SARS-CoV-2. All recombinant nucleocapsid clones display high affinity for human cell-expressed full-length SARS-CoV-2 nucleocapsid protein, with EC50 values ranging from 0.006-0.074 nM. The SARS-CoV-2 nucleocapsid recombinant antibody pair (GTX635689 and GTX635686) demonstrates superior sensitivity for sandwich ELISA and lateral flow assays. As with the spike antibody catalog, GeneTex’s extensive nucleocapsid antibody listing includes products ideal for all common applications.

GeneTex is using indirect ELISA assays to rigorously test the affinities of several of its spike antibodies for recombinant variant spike (ECD) proteins. Please see the chart below documenting current progress.

 

Targeted Region of Spike Antibody Cat. No. WIV04/2019 (reference sequence) 501Y.V1 501Y.V2 501Y.V3
RBD GTX635807 N/A
RBD GTX635792 N/A
RBD GTX635793 N/A
S1 GTX635713 N/A
S1 GTX635708 X X N/A
S2 GTX632604 N/A
S2 GTX635693 N/A

 

  Strong reaction. Defined as OD450 value >1 when 1μg/ml protein was used.
  Weak reaction. Defined as OD450 value >1 when 4μg/ml protein was used.
X   No reaction. Defined as OD450 value <1 when 4μg/ml protein was used.
N/A   Not performed.

 

Full Listing of Products for SARS-CoV-2 (COVID-19) Research

Anti-Spike Antibodies | Anti-Nucleocapsid Antibodies | Other Antibodies | Binding / Neutralization Assay Panel | ELISA Pairs | ELISA Kit | Lateral Flow Recommended Pairs | Recombinant Proteins | Cell Pellet Blocks | Overexpression Lysates | Products for Host Cell Entry Research | Featured Antibodies | Highlighted ELISA Pairs | Highlighted Proteins

 

Anti-Spike Antibodies

Recombinant Citation-Support Protein Overexpression 

  Product Name Clonality EC50 Applications Cat. No.
Spike S1 antibody [HL1] Rb recAb 117 pM WB, ICC/IF, ELISA, Sandwich ELISA GTX635656
Spike S1 antibody [HL6] Rb recAb 251 pM WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA, FACS, IHC-P GTX635654
Spike S1 antibody [HL134] Rb recAb 552 pM WB, ICC/IF, IHC-P (cell pellet), ELISA GTX635671
Spike S1 antibody [HL263] Rb recAb 365 pM WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635672
Spike S1 antibody [HL13402] Rb recAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX635713
Spike S1 antibody [GT263] Ms mAb   WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635708
  Spike S1 antibody Rb pAb   WB, ICC/IF, ELISA GTX135384
  Spike RBD antibody [HL1002] Rb recAb   Neutralizing/Inhibition GTX635791
Spike RBD antibody [HL1003] Rb recAb 7.49 pM ICC/IF, ELISA, Neutralizing/Inhibition,Sandwich ELISA GTX635792
Spike RBD antibody [HL1003-HU] Hu recAb   Neutralizing/Inhibition GTX635866
Spike RBD antibody [HL1004] Rb recAb 25.13 pM ICC/IF, ELISA, Sandwich ELISA, Neutralizing/Inhibition GTX635793
Spike RBD antibody [HL1004] (HRP) Rb recAb   ELISA, Sandwich ELISA GTX635793-01
Spike RBD antibody [HL1014] Rb recAb 28.77 pM ICC/IF, ELISA, Sandwich ELISA GTX635807
Spike RBD antibody [HL257] Rb recAb   WB, ICC/IF, IHC-P, ELISA, IHC-P (cell pellet) GTX635692
  Spike RBD antibody Rb pAb   WB, FACS, Neutralizing/Inhibition, ICC/IF, ELISA, IHC-P (cell pellet) GTX135709
  Spike RBD antibody Rb pAb   WB, ICC/IF GTX135385
Spike S2 antibody [HL237] Rb recAb   WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635693
  Spike S2 / S2' antibody Rb pAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX135386
Spike antibody [1A9] Ms mAb   WB, ICC/IF, IHC-P, IHC-P (cell pellet), FACS, IP, ELISA, Sandwich ELISA GTX632604
  Spike antibody Rb pAb   WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX135356
  Spike antibody Rb pAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX135360
Spike antibody [CR3022] Hu recAb   ELISA, Neutralizing/Inhibition GTX01555
Spike antibody [CR3022-RB] Rb recAb   ELISA, Neutralizing/Inhibition GTX01556

 

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Anti-Nucleocapsid Antibodies

Recombinant Citation-Support Protein Overexpression 

  Product Name Clonality EC50 Applications Cat. No.
Nucleocapsid antibody [HL455-MS] Ms mAb   WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635712
Nucleocapsid antibody [HL5410] Rb recAb 9 pM WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635685
Nucleocapsid antibody [HL5410] (Gold) Rb recAb   Immunoassay GTX635685-17
  Nucleocapsid antibody [HL5511] Rb recAb 14 pM WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635689
Nucleocapsid antibody [HL146] Rb recAb 50 pM WB, ICC/IF, ELISA, Sandwich ELISA GTX635680
Nucleocapsid antibody [HL249] Rb recAb 16 pM WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635678
Nucleocapsid antibody [HL344] Rb recAb 74 pM WB, ICC/IF, IHC-P, IHC-P (cell pellet), IHC-Fr, ELISA, Sandwich ELISA GTX635679
Nucleocapsid antibody [HL448] Rb recAb 11 pM WB, ICC/IF, IHC-P, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635686
Nucleocapsid antibody [HL448] (HRP) Rb recAb   ELISA, Sandwich ELISA, WB GTX635686-01
Nucleocapsid antibody [HL453] Rb recAb 6 pM WB, ICC/IF, IHC-P (cell pellet), ELISA GTX635687
Nucleocapsid antibody [HL455] Rb recAb 6 pM WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635688
  Nucleocapsid antibody [GT113] Ms mAb   WB GTX635808
  Nucleocapsid antibody [6H3] Ms mAb   WB, ICC/IF, IHC-P (cell pellet), IP, ELISA, Sandwich ELISA GTX632269
Nucleocapsid antibody Rb pAb   WB, ICC/IF, IHC-P, IHC-P (cell pellet), FACS, IP, ELISA, Sandwich ELISA GTX135357
  Nucleocapsid antibody Rb pAb   WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX135361

 

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Other SARS-CoV-2 Antibodies

Citation-Support  

  Product Name Clonality Applications Cat. No.
  RdRp (nsp12) antibody Rb pAb WB, ICC/IF GTX135467
  RdRp (nsp12) antibody Rb pAb WB GTX135469
  3CLpro (nsp5) antibody Rb pAb WB GTX135470
  ORF8 antibody Rb pAb WB, ICC/IF GTX135591
  nsp1 antibody Rb pAb WB GTX135586
  nsp1 antibody Rb pAb WB, ICC/IF GTX135612
  nsp2 antibody Rb pAb WB GTX135717
  PLpro (nsp3) antibody Rb pAb WB, ICC/IF GTX135589
  PLpro (nsp3) antibody Rb pAb WB, ICC/IF GTX135614
ORF7a antibody [3C9] Ms mAb WB, ICC/IF GTX632602
nsp8 antibody [5A10] Ms mAb WB, ICC/IF, FACS GTX632696
  nsp8 antibody Rb pAb WB GTX135729
  nsp8 antibody Rb pAb WB GTX135730
  nsp9 antibody Rb pAb WB GTX135731
  nsp9 antibody Rb pAb WB GTX135732
  nsp10 antibody Rb pAb WB GTX135733
  nsp10 antibody Rb pAb WB GTX135734
  nsp15 antibody Rb pAb WB GTX135737
  nsp15 antibody Rb pAb WB GTX135738
  nsp11 antibody Rb pAb WB GTX135742

 

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Binding / Neutralization Assay Panel

Product Name Applications Cat. No.
RBD ACE2 Binding Activity / Neutralization Assay Panel Neutralizing/Inhibition GTX300122

 

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ELISA Antibody Pairs

Product Name Sensitivity Cat. No.
Spike RBD ELISA Pair [HL1014 / HL1003]   GTX500046
Spike RBD ELISA pair [HL1014/HL1004]   GTX500047
Spike ELISA Pair [1A9 / HL263]   GTX500041
Spike ELISA Pair [1A9 / HL6]   GTX500040
Spike ELISA Pair [1A9 / HL13402]   GTX500043
Nucleocapsid ELISA Pair [HL5511 / HL448] 39.06 pg/mL GTX500045
Nucleocapsid ELISA Pair [HL5410 / HL455-MS] 2.68 pg/mL GTX500042

 

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SARS-CoV-2 Nucleocapsid ELISA Kit

Product Name Sensitivity Applications Cat. No.
Nucleocapsid Protein Sandwich ELISA Kit 18 pg/ml ELISA, Sandwich ELISA GTX535824

 

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Lateral Flow Assay (Recommended Antibody Pairs)

Recombinant 

Antibody Pair   Product Name Clonality EC50 Cat. No.
Pair I   Nucleocapsid antibody [HL5511] Rb recAb 14 pM GTX635689
Nucleocapsid antibody [HL448] Rb recAb 11 pM GTX635686
Pair II Nucleocapsid antibody [HL5410] Rb recAb 9 pM GTX635685
Nucleocapsid antibody [HL455] Rb recAb 6 pM GTX635688

 

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Recombinant Proteins

Product Name Expression System Applications Cat. No.
Spike (ECD) protein, His tag (active) HEK293 Functional Assay GTX02774-pro
Spike (ECD) protein, His tag (active) HEK293 ELISA, Functional Assay GTX135972-pro
Spike (D614G Mutant) protein (ECD), His tag (active) HEK293   GTX02575-pro
Spike (del69-70,del144,N501Y,A570D,D614G,...) (ECD) Protein, His tag (active) HEK293   GTX136059-pro
Spike (L18F,..., K417T, E484K, N501Y, D614G,...,V987P)(ECD), His tag (active) HEK293   GTX136091-pro
Spike S1 (del69-70, del44, N501Y, A570D, D614G...) Protein, His tag (active) HEK293   GTX136085-pro
Spike S1 (L18F..., R190S, K417T, E484K, N501Y, D614G, H655Y), His tag (active) HEK293  

GTX136094-pro

Spike S1 (L18F, D80A,..., R246I, K417N, E484K, N501Y, D614G), His tag (active) HEK293  

GTX136095-pro

Spike S1 protein, His tag (active) HEK293 ELISA, Functional Assay GTX01554-pro
Spike S1 protein, His and Avi tag (active) HEK293 ELISA, Functional Assay GTX01548-pro
Spike S1 protein, His tag (active) HEK293 WB, ELISA, Functional Assay, Sandwich ELISA GTX135817-pro
Spike S2 (ECD) protein, mouse IgG Fc tag HEK293 WB, ELISA, Sandwich ELISA GTX135684-pro
Spike S2 (ECD) protein, human IgG Fc tag HEK293   GTX01559-pro
Spike S2 (T716I, S982A, D1118H Mutant) (ECD) protein, His tag HEK293 WB GTX136023-pro
Spike RBD (E484K, N501Y Mutant) protein, His tag (active) HEK293   GTX136058-pro
Spike RBD (N501Y Mutant) protein, His tag (active) HEK293 WB, ELISA, Functional Assay

GTX136014-pro

Spike RBD (K417N, E484K, N501Y Mutant) protein, His tag (active) HEK293 WB, Functional Assay

GTX136022-pro

Spike RBD (K417T, E484K, N501Y Mutant) protein, His tag HEK293   GTX136043-pro
Spike RBD protein, His tag (active) HEK293 Functional Assay GTX136090-pro
Spike RBD protein, His tag (active) HEK293 Functional Assay GTX01546-pro
Nucleocapsid protein, His tag E. coli ELISA, Sandwich ELISA GTX135357-pro
Nucleocapsid protein, His tag HEK293 WB, ELISA, Sandwich ELISA GTX135592-pro
Nucleocapsid protein,His tag (Gold) HEK293 Immunoassay GTX135746-pro
Envelope protein, His and Avi tag E. coli   GTX01547-pro
Envelope Protein, GST and His Tag HEK293   GTX01565-pro
3CLpro (nsp5) protein, His tag E. coli WB GTX135648-pro
3CLpro (nsp5) protein, His and Avi tag E. coli   GTX01557-pro

 

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Cell Pellet Blocks

Product Name Applications Cat. No.
Spike FFPE 293T cell pellet block IHC-P (cell pellet) GTX435640
Spike S1 FFPE 293T cell pellet block IHC-P (cell pellet) GTX435643
Spike S2 FFPE 293T cell pellet block IHC-P (cell pellet) GTX435644
Nucleocapsid FFPE 293T cell pellet block IHC-P (cell pellet) GTX435641
Envelope FFPE 293T cell pellet block IHC-P (cell pellet) GTX435642
Membrane FFPE 293T cell pellet block IHC-P (cell pellet) GTX435645

 

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Overexpression Lysates

Product Name Applications Cat. No.
Spike overexpression 293T whole cell lysate WB, ELISA GTX535664
Spike S1 overexpression 293T whole cell lysate WB GTX535663
Nucleocapsid overexpression 293T whole cell lysate WB, ELISA GTX535665

 

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Products for Host Cell Entry Research

Recombinant Citation-Support KOKD-Validation Protein Overexpression

  Product Name Clonality or Expression System Applications Cat. No.
  ACE2 antibody [GT19410] Ms mAb IHC-P, ELISA

GTX635897

   ACE2 antibody [N1N2], N-term Rb pAb WB, ICC/IF, IHC-P, FACS, ELISA GTX101395
  ACE2 antibody [SN0754] Rb recAb WB, ICC/IF, IHC-P GTX01160
  ACE2 antibody Rb pAb WB, ICC/IF, IHC-P, ELISA GTX15349
  Human ACE2(ECD) protein, mouse IgG Fc tag HEK 293 WB, ELISA, Functional Assay GTX135683-pro
  Human ACE2 protein, His and Avi tag HEK 293 ELISA GTX01550-pro
  TMPRSS2 antibody [N2C3] Rb pAb WB, IHC-P GTX100743
  Camostat mesylate   TMPRSS2 inhibitor GTX01523

 

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Featured Antibodies

Recombinant Citation-Support Protein Overexpression

 

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] (GTX632604)

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] 
(GTX632604)

Protein Overexpression
SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344]

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344]
 (GTX635679)

SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344]

SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1003] (GTX635792)

SARS-CoV-2 (COVID-19) Spike S1 antibody [HL13402]

SARS-CoV-2 (COVID-19) Spike S1 antibody [HL13402] (GTX635713)

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ELISA Kits and Pairs 

Nucleocapsid Protein Sandwich ELISA Kit

Nucleocapsid Protein Sandwich ELISA Kit 
(GTX535824)

Spike RBD ELISA pair [HL1014/HL1004]

Spike RBD ELISA pair [HL1014/HL1004] (GTX500047)

Spike RBD ELISA Pair [HL1014 / HL1003]

Spike RBD ELISA Pair [HL1014 / HL1003] (GTX500046)

Spike ELISA Pair [1A9 / HL13402]

Spike ELISA Pair [1A9 / HL13402] (GTX500043)

 

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Highlighted Proteins 

SARS-CoV-2 (COVID-19) Spike (ECD) protein, His tag (active)

SARS-CoV-2 (COVID-19) Spike (ECD) protein, His tag (active)
(GTX135972-pro)

SARS-CoV-2 (COVID-19) Spike RBD (K417N, E484K, N501Y Mutant) protein, His tag (active)

SARS-CoV-2 (COVID-19) Spike RBD (K417N, E484K, N501Y Mutant) protein, His tag (active)
(GTX136022-pro)

SARS-CoV-2 (COVID-19) Spike RBD (N501Y Mutant) protein, His tag (active)

SARS-CoV-2 (COVID-19) Spike RBD (N501Y Mutant) protein, His tag (active)
(GTX136014-pro)

SARS-CoV-2 (COVID-19) Spike RBD (N501Y Mutant) protein, His tag (active)

SARS-CoV-2 (COVID-19) Spike RBD (K417T, E484K, N501Y Mutant) protein, His tag (GTX136043-pro)

 

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