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Epithelial–mesenchymal transition (EMT) Pathway


Epithelial–mesenchymal transition (EMT) is a process whereby tightly-interacting and immotile epithelial cells acquire the phenotype of loosely-adherent and motile mesenchymal cells. EMT not only facilitates morphogenesis during embryonic development but also promotes invasion and metastasis in tumors. Pathological EMT is associated with E-cadherin repression, which has been shown to contribute to tumor progression. Several oncogenic pathways (TGF-β, Wnt/β-catenin, Integrins, Notch, etc) have been reported to induce EMT via cytoskeleton reorganization and activation of E-Cadherin repressors, including Snail, Slug, SIP1, and TCF3. GeneTex is proud to introduce our new line of antibodies for the study of EMT.