A Rising StAR in Cancer Research

Steroidogenic acute regulatory protein 1 (StAR/StARD1) mediates the rate-limiting step in steroidogenesis, which is the transport of cholesterol from the outer to the inner mitochondrial membrane. Subsequent modification of cholesterol by CYP11A1 generates pregnenolone, a steroid hormone precursor. Another cytochrome P450 enzyme, CYP27A1, is a crucial factor in bile acid biosynthesis from cholesterol. In their recent study, Conde de la Rosa et al. describe the pivotal role of StAR in the development of non-alcoholic steatohepatitis-driven hepatocellular carcinoma (NASH-driven HCC) through stimulation of bile acid synthesis via an alternative mitochondrial pathway (1). The authors report that increased expression of StAR in HCC correlated with bile acid accumulation in the liver, and that this resulted in products that promoted gene expression related to stemness and inflammation. This not only makes StAR a valued prognostic marker, but also a possible therapeutic target for some cases of HCC.

GeneTex offers an extensive catalog of well-validated reagents for cancer research, including the new recombinant rabbit monoclonal StAR antibody and the CYP11A1 and CYP27A1 rabbit polyclonal antibodies shown below. Please review the highlighted product images and visit our website at www.genetex.com for more details.

Highlighted Products

StAR antibody [HL1360] (GTX636800)

StAR antibody [HL1360] (GTX636800)

CYP11A1 antibody (GTX56293)

CYP27A1 antibody (GTX103718)

Cat. No. Product Name Applications   GTX105716 StAR antibody WB, ICC/IF, IHC-P    GTX114187 VDAC1 antibody [N1C2] WB, IHC-P   GTX104745 VDAC2 antibody [C2C3], C-term WB, ICC/IF, IHC-P, IP, ELISA GTX636967 TOMM20 antibody [HL1493] WB, IHC-P GTX133756 TOMM20 antibody WB, ICC/IF, IHC-P    GTX133780 TOMM40 antibody WB, IHC-P GTX116439 TOMM34 antibody [N1C3] WB, ICC/IF, IHC-P   GTX112784 UCP1 antibody WB, IHC-P   GTX132072 UCP2 antibody WB

Reference:

1. J Hepatol. 2021 Jun;74(6):1429-1441. doi: 10.1016/j.jhep.2021.01.028.