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A Rising StAR in Cancer Research

A Rising StAR in Cancer Research


Steroidogenic acute regulatory protein 1 (StAR/StARD1) mediates the rate-limiting step in steroidogenesis, which is the transport of cholesterol from the outer to the inner mitochondrial membrane. Subsequent modification of cholesterol by CYP11A1 generates pregnenolone, a steroid hormone precursor. Another cytochrome P450 enzyme, CYP27A1, is a crucial factor in bile acid biosynthesis from cholesterol. In their recent study, Conde de la Rosa et al. describe the pivotal role of StAR in the development of non-alcoholic steatohepatitis-driven hepatocellular carcinoma (NASH-driven HCC) through stimulation of bile acid synthesis via an alternative mitochondrial pathway (1). The authors report that increased expression of StAR in HCC correlated with bile acid accumulation in the liver, and that this resulted in products that promoted gene expression related to stemness and inflammation. This not only makes StAR a valued prognostic marker, but also a possible therapeutic target for some cases of HCC.


GeneTex offers an extensive catalog of well-validated reagents for cancer research, including the new recombinant rabbit monoclonal StAR antibody and the CYP11A1 and CYP27A1 rabbit polyclonal antibodies shown below. Please review the highlighted product images and visit our website at for more details.


Highlighted Products

  Orthogonal Validation Protein Overexpression 

StAR antibody [HL1360] (GTX636800)

StAR antibody [HL1360]

StAR antibody [HL1360] (GTX636800)

StAR antibody [HL1360]

CYP11A1 antibody (GTX56293)

CYP11A1 antibody

CYP27A1 antibody (GTX103718)

CYP27A1 antibody

Cat. No. Product Name Applications  
GTX105716 StAR antibody WB, ICC/IF, IHC-P Citation-Support Orthogonal Validation Protein Overexpression
GTX114187 VDAC1 antibody [N1C2] WB, IHC-P Citation-Support Orthogonal Validation
GTX104745 VDAC2 antibody [C2C3], C-term WB, ICC/IF, IHC-P, IP, ELISA Citation-Support
GTX636967 TOMM20 antibody [HL1493] WB, IHC-P Recombinant
GTX133756 TOMM20 antibody WB, ICC/IF, IHC-P Citation-Support Comparable Abs Orthogonal Validation
GTX133780 TOMM40 antibody WB, IHC-P Orthogonal Validation
GTX116439 TOMM34 antibody [N1C3] WB, ICC/IF, IHC-P  
GTX112784 UCP1 antibody WB, IHC-P Citation-Support Orthogonal Validation
GTX132072 UCP2 antibody WB Citation-Support




  1. J Hepatol. 2021 Jun;74(6):1429-1441. doi: 10.1016/j.jhep.2021.01.028.