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NEK7: An Essential Regulator of NLRP3 Inflammasome Activation

NEK7: An Essential Regulator of NLRP3 Inflammasome Activation

 

NEK7 is the smallest of the eleven (NEK1-NEK11) mammalian NIMA-related kinase (NEK) family serine/threonine kinases and is expressed in many tissues. Its importance in mitotic regulation and NLRP3 inflammasome activation has been established, with inflammasome activation involving NEK7’s direct binding to NLRP3. Inflammasome activation is associated with pyroptosis and mediates the release of pro-inflammatory cytokines IL-1β and IL-18 and the cleavage of pore-forming gasdermin D. Pyroptosis is linked to many inflammatory diseases, and thus therapeutic targeting of NEK7-mediated inflammasome activation continues to be an exciting field of research (1). 

 

GeneTex offers a diverse selection of high-quality reagents to study inflammation. These antibodies are validated for various applications, including western blot, ICC/IF, and IHC-P. Please see the highlighted products below and visit www.genetex.com for more details.

 

Highlighted Products

   

NEK7 antibody [HL1348] (GTX636768)

NEK7 antibody [HL1348] (GTX636768)
NLRP3 antibody (GTX133569)

NLRP3 antibody (GTX133569)
IL1 beta antibody [HL1421] (GTX636887)

IL1 beta antibody [HL1421] (GTX636887)
Gasdermin D antibody [HL1430] (GTX636896)

Gasdermin D antibody [HL1430] (GTX636896)

 

Cat. No. Product Name Applications
GTX110520 TNF alpha antibody WB, ICC/IF, IHC-P, IHC-Fr
GTX101322 Caspase 1 antibody [N1N3] WB, ICC/IF, IHC-P
GTX116840 Gasdermin D antibody [N1N3] WB
GTX107678 NFkB p65 antibody WB, ICC/IF, IHC-P, IP, EMSA
GTX102090 NFkB p65 antibody WB, ICC/IF, IHC-P, IHC-Fr, IP, ChIP assay
GTX102474 TMS1 antibody [N1C3] WB, ICC/IF, IHC-P, IHC-Fr
GTX74034 IL1 beta antibody WB, ICC/IF, IHC-P, IHC-Fr, ELISA, IHC
GTX130021 IL1 beta antibody WB, ICC/IF

 

 

Reference:

1.Front Physiol. 2020; 11: 606996.